浙江预防医学
浙江預防醫學
절강예방의학
ZHEJIANG JOURNAL OF PREVENTIVE MEDICINE
2015年
4期
325-327,333
,共4页
陈深侠%谢锦荣%赵中飞%陈恩富%张政
陳深俠%謝錦榮%趙中飛%陳恩富%張政
진심협%사금영%조중비%진은부%장정
儿童%W135群脑膜炎奈瑟菌%免疫水平
兒童%W135群腦膜炎奈瑟菌%免疫水平
인동%W135군뇌막염내슬균%면역수평
Population%Neisseria meningitis serogroup W1 35%Immunity level
目的:调查健康人群 W135群脑膜炎奈瑟菌免疫水平,为制定含 W135群流脑疫苗免疫程序提供依据。方法2011年在诸暨市按东西南北中选择5个乡镇/街道,分层随机抽取410名0~14岁无流脑病史和免疫史的本地健康儿童及同乡镇≥15岁健康居民并采集血样,用 ELISA 法检测 W135群脑膜炎奈瑟菌多糖抗体(IgG)浓度, IgG 浓度≥2μg/mL 为阳性。结果410名儿童 W135群脑膜炎奈瑟菌抗体平均浓度为(1.46±0.25)μg/mL,抗体阳性率为4.63%。儿童 W135群脑膜炎奈瑟菌抗体浓度及阳性率在地区、性别差异均无统计学意义(P >0.05)。儿童各年龄组间抗体平均浓度差异有统计学意义(P <0.05)。15岁~组抗体浓度(1.63±0.28)μg/mL 高于其他年龄组(P <0.05);1.5岁~组抗体浓度(1.37±0.19)μg/mL 低于5岁~组(1.55±0.29)μg/mL (P <0.05),与0岁~组(1.50±0.25)μg/mL 比较差异无统计学意义(P >0.05);60岁~组抗体浓度(1.29±0.20)μg/mL 低于0岁~和5岁~组(P <0.05)。结论健康儿童的 W135群脑膜炎奈瑟菌免疫水平普遍较低,建议在适当的年龄开展含 W135群流脑疫苗接种。
目的:調查健康人群 W135群腦膜炎奈瑟菌免疫水平,為製定含 W135群流腦疫苗免疫程序提供依據。方法2011年在諸暨市按東西南北中選擇5箇鄉鎮/街道,分層隨機抽取410名0~14歲無流腦病史和免疫史的本地健康兒童及同鄉鎮≥15歲健康居民併採集血樣,用 ELISA 法檢測 W135群腦膜炎奈瑟菌多糖抗體(IgG)濃度, IgG 濃度≥2μg/mL 為暘性。結果410名兒童 W135群腦膜炎奈瑟菌抗體平均濃度為(1.46±0.25)μg/mL,抗體暘性率為4.63%。兒童 W135群腦膜炎奈瑟菌抗體濃度及暘性率在地區、性彆差異均無統計學意義(P >0.05)。兒童各年齡組間抗體平均濃度差異有統計學意義(P <0.05)。15歲~組抗體濃度(1.63±0.28)μg/mL 高于其他年齡組(P <0.05);1.5歲~組抗體濃度(1.37±0.19)μg/mL 低于5歲~組(1.55±0.29)μg/mL (P <0.05),與0歲~組(1.50±0.25)μg/mL 比較差異無統計學意義(P >0.05);60歲~組抗體濃度(1.29±0.20)μg/mL 低于0歲~和5歲~組(P <0.05)。結論健康兒童的 W135群腦膜炎奈瑟菌免疫水平普遍較低,建議在適噹的年齡開展含 W135群流腦疫苗接種。
목적:조사건강인군 W135군뇌막염내슬균면역수평,위제정함 W135군류뇌역묘면역정서제공의거。방법2011년재제기시안동서남북중선택5개향진/가도,분층수궤추취410명0~14세무류뇌병사화면역사적본지건강인동급동향진≥15세건강거민병채집혈양,용 ELISA 법검측 W135군뇌막염내슬균다당항체(IgG)농도, IgG 농도≥2μg/mL 위양성。결과410명인동 W135군뇌막염내슬균항체평균농도위(1.46±0.25)μg/mL,항체양성솔위4.63%。인동 W135군뇌막염내슬균항체농도급양성솔재지구、성별차이균무통계학의의(P >0.05)。인동각년령조간항체평균농도차이유통계학의의(P <0.05)。15세~조항체농도(1.63±0.28)μg/mL 고우기타년령조(P <0.05);1.5세~조항체농도(1.37±0.19)μg/mL 저우5세~조(1.55±0.29)μg/mL (P <0.05),여0세~조(1.50±0.25)μg/mL 비교차이무통계학의의(P >0.05);60세~조항체농도(1.29±0.20)μg/mL 저우0세~화5세~조(P <0.05)。결론건강인동적 W135군뇌막염내슬균면역수평보편교저,건의재괄당적년령개전함 W135군류뇌역묘접충。
Objective To learn the immunity level of Neisseria meningitides (Nm) serogroup W1 35 among healthy population.Methods A total of 410 children aged 0 -14 years were selected by stratified random sampling method in Zhuji city.The polysaccharide antibody IgG level of Nm serogroup W1 35 was detected by ELISA.The antibody concentrations more than 2 μg/mL were identified as positive.Results The geometric mean concentration (GMC)was 1.46 ±0.25 μg/mL and the W1 35 -antibody positive rate was 4.63%.There was no difference on antibody GMC and the W1 35 -antibody postive rate among different region and gender groups.There were statistical differences on antibody GMC among different age groups (P<0.05).The antibody GMT in the age group 15 -34(1.63 ±0.28 μg/mL )was significantly higher than that in other age groups(P <0.05),and the antibody GMT in the age group 1.5 -4 (1.37 ±0.19 μg/mL)was significantly lower than that in the age group 5 -14 (P <0.05).The antibody GMT were significantly lower in the elderly (≥60 years old)than that in the age group <10 and 5 -14(P <0.05).Conclusion The immunity level of Nm serogroup W1 35 among healthy population is low,and it is suggested to be immunized by the vaccines which contained Nm W1 35.