CAJ | 학술논문

脑部分子影像对于脑功能和神经疾病发病机理研究以及早期诊断有重大意义，多巴胺受体系统与人的情绪、爱情、成瘾、奖励机制和一些疾病有重要的联系。本文以新型脑神经多巴胺受体D2/D3显像剂18F-fallypride为例，探讨了18F-fallypride的研究发展和应用趋势，并应用自主研发的AMIC Ray-Scan 64 PET/CT成像系统对15例健康志愿者进行了临床研究，图像上观测到纹状体和外纹状体的信号清晰，药物分布均匀、对称。此外，脑肿瘤细胞凋亡显像剂18F-ML-10新药可对脑肿瘤的放射性治疗效果进行评估，本文综述了18F-ML-10临床应用的发展，并对10例脑瘤患者接受放射性治疗前后的细胞凋亡情况进行了对比评估，并通过图像对放射性治疗给出评价。
뇌부분자영상대우뇌공능화신경질병발병궤리연구이급조기진단유중대의의，다파알수체계통여인적정서、애정、성은、장려궤제화일사질병유중요적련계。본문이신형뇌신경다파알수체D2/D3현상제18F-fallypride위례，탐토료18F-fallypride적연구발전화응용추세，병응용자주연발적AMIC Ray-Scan 64 PET/CT성상계통대15례건강지원자진행료림상연구，도상상관측도문상체화외문상체적신호청석，약물분포균균、대칭。차외，뇌종류세포조망현상제18F-ML-10신약가대뇌종류적방사성치료효과진행평고，본문종술료18F-ML-10림상응용적발전，병대10례뇌류환자접수방사성치료전후적세포조망정황진행료대비평고，병통과도상대방사성치료급출평개。
Brain molecular imaging plays an important role in investigations on the function of brain and mechanism of neural diseases. The dopaminergic receptor system is closely related with emotion, love, addiction, incentives, many diseases and disorders. Hereby, taking 18F-fallypride as an example of novel dopamine receptor D2/D3 probes visualizing the Dopamine D2/D3 receptors in striatal and extra-striatal areas, this paper reviews the trends of R&D(Research and Development) and clinical applications of 18F-fallypride, and investigates 18F-fallypride with 15 healthy volunteers’ brain imaging by using the self-innovated AMIC Ray-Scan 64 PET/CT. The result shows a homogeneous and symmetrical distribution of signal in striatal and extra-striatal areas, indicating that the 18F-fallypride, as well as Ray-Scan 64 PET/CT, has demonstrated an excellent performance in dopamine receptor imaging. Additionally, this paper also reviews the progress of clinical uses of 18F-ML-10, a molecular probe to visualize apoptosis. Besides, 10 patients with brain tumorsare investigated by 18F-ML-10-PET/CT imaging pre-and post-radiation with AMIC Ray-Scan 64 PET/CT, in order to evaluate the effect of treatments.