CAJ | 학술논문

目的：探讨临床药师干预对抗菌药物合理用药的影响。方法选取2012年4月至2013年4月未实施干预前住院患者1000例（对照组），另外选取2013年5月至2014年5月实施干预后的住院患者1000例（观察组），比较两组抗菌药物使用率、住院时间、住院费用、抗菌药物使用费用。结果观察组抗菌药物使用率56．0％（560／1000），显著低于对照组抗菌药物使用率的78．0％（780／1000）（χ2＝11．089，P＝0.032）；观察组住院时间、抗菌药物使用费用分别为（12．6±0．8）d、（912．2±13．2）元，显著优于对照组的（16．9±0．7）d、（1528．1±32．5）元（t＝9．892、10．142，P＝0．028、0．014）；两组住院费用差异无统计学意义（t＝4．984，P＝0．072）。结论临床药师干预对抗菌药物的合理应用具有促进作用，能显著降低抗菌药物的使用率，减少住院时间。
목적：탐토림상약사간예대항균약물합리용약적영향。방법선취2012년4월지2013년4월미실시간예전주원환자1000례（대조조），령외선취2013년5월지2014년5월실시간예후적주원환자1000례（관찰조），비교량조항균약물사용솔、주원시간、주원비용、항균약물사용비용。결과관찰조항균약물사용솔56．0％（560／1000），현저저우대조조항균약물사용솔적78．0％（780／1000）（χ2＝11．089，P＝0.032）；관찰조주원시간、항균약물사용비용분별위（12．6±0．8）d、（912．2±13．2）원，현저우우대조조적（16．9±0．7）d、（1528．1±32．5）원（t＝9．892、10．142，P＝0．028、0．014）；량조주원비용차이무통계학의의（t＝4．984，P＝0．072）。결론림상약사간예대항균약물적합리응용구유촉진작용，능현저강저항균약물적사용솔，감소주원시간。
Objective To study the effect of clinical pharmacist interventions on the rational use of antibiot-ics.Methods 1 000 hospitalized patients before the implementation of intervention in April 2012 to April 2013 (control group)and the other 1 000 cases of hospitalized patients in May 2013 to May 2014 after the implementation of the intervention (study group)were selected,the antibiotics use rate,hospitalization time and cost,cost of using antibacterial drugs were compared between the two groups.Results The antibiotics use rate of the study group was 56.0%(560/1 000),significantly lower than 78%(780/1 000)of the control group,with significant differences between the two groups(χ2 =11.089,P=0.032),the hospitalization time,cost of using antibacterial drugs of the study group were (12.6 ±0.8)days,(912.2 ±13.2)yuan,significantly better than (16.9 ±0.7)days,(1 528.1 ± 32.5)yuan of the control group,with significant differences between the two groups (t=9.892,10.142,P=0.028, 0.014);The two groups of hospitalization expenses showed no statistical significance (t =4.984,P =0.072 ). Conclusion Clinical pharmacist intervention has a positive effect on the application of antibacterial drugs,which can significantly reduce the use of antimicrobial drugs and reduce the hospitalization days.