CAJ | 학술논문

恶性肿瘤的靶向治疗已经成为现阶段肿瘤治疗的热点。随着人们对癌基因认知的加深，借助合成致死的方法靶向治疗肿瘤已成为针对肿瘤特异性治疗的新策略。p53基因突变在肿瘤的形成和发展过程中具有重要作用。因此，了解肿瘤中与突变型p53基因有合成致死关系的靶基因的作用方式，有助于指导由突变型p53基因诱发肿瘤的个性化治疗。与突变型p53基因具有合成致死关系的靶基因可分为细胞周期调控基因和细胞非周期调控基因，文章综述了这两类靶基因与突变型p53基因如何构成合成致死作用以及此作用的现实意义。
악성종류적파향치료이경성위현계단종류치료적열점。수착인문대암기인인지적가심，차조합성치사적방법파향치료종류이성위침대종류특이성치료적신책략。p53기인돌변재종류적형성화발전과정중구유중요작용。인차，료해종류중여돌변형p53기인유합성치사관계적파기인적작용방식，유조우지도유돌변형p53기인유발종류적개성화치료。여돌변형p53기인구유합성치사관계적파기인가분위세포주기조공기인화세포비주기조공기인，문장종술료저량류파기인여돌변형p53기인여하구성합성치사작용이급차작용적현실의의。
Targeted therapy has become a powerful approach for cancer treatment. Better understanding of onco-genes as well as synthetic lethal interactions with oncogenes will lead to new strategies for tumor-specific treatment. It is well known that mutant p53 plays an important role in tumorigenesis and tumor development. Thus, understand-ing the synthetic lethal relationship between p53 mutations and interacting genes in tumor is critical for the personal-ized treatments of p53 mutant tumors. Synthetic lethal genes to mutant p53 can be divided into cell cycle regulators and non-cell cycle regulators. This paper review show these two types of target genes contribute to synthetic lethal interactions with p53 mutations and potential applications of these interactions in anticancer therapy.