CAJ | 학술논문

心血管疾病严重威胁人类的健康和生活质量，目前已成为导致人类死亡的头号杀手。因此，寻找有效的治疗药物以降低该病的致死率和致残率成为亟待解决的问题。丹参因其具有较好的活血化瘀功效，目前已被广泛的用于心血管疾病的治疗且取得较好的疗效。丹酚酸 B 是丹参提取物中的主要水溶性成分之一，研究证实丹酚酸 B 具有多种药理活性，不仅对心肌梗死（myocardial infarction，MI）具有很好的保护作用，同时也能够明显的改善心肌缺血／再灌注（myo-cardial ischemia-reperfusion，MI ／R）的损伤。该文就近年来丹酚酸 B 在心血管疾病中的药理研究进展进行综述，阐述丹酚酸 B 调控心血管疾病的药理作用机制及其与心血管疾病治疗的关系，为丹酚酸 B 的临床应用及后续研究提供参考。
심혈관질병엄중위협인류적건강화생활질량，목전이성위도치인류사망적두호살수。인차，심조유효적치료약물이강저해병적치사솔화치잔솔성위극대해결적문제。단삼인기구유교호적활혈화어공효，목전이피엄범적용우심혈관질병적치료차취득교호적료효。단분산 B 시단삼제취물중적주요수용성성분지일，연구증실단분산 B 구유다충약리활성，불부대심기경사（myocardial infarction，MI）구유흔호적보호작용，동시야능구명현적개선심기결혈／재관주（myo-cardial ischemia-reperfusion，MI ／R）적손상。해문취근년래단분산 B 재심혈관질병중적약리연구진전진행종술，천술단분산 B 조공심혈관질병적약리작용궤제급기여심혈관질병치료적관계，위단분산 B 적림상응용급후속연구제공삼고。
Cardiovascular disease is a serious threat to human health and quality of life ,and it has become the leading cause of death in human.Thus,looking for effective drugs to reduce the mortality and morbidity of such a disease has become a problem to be solved.Due to its good efficacy of activating blood circula-tion and dissipating blood stasis,salvia miltiorrhiza has been widely used in the treatment of cardiovascular disease and ob-tained a good curative effect.Salvianolic acid B is one of the main water-soluble components of salvia miltiorrhiza extract and studies have shown that salvianolic acid B possesses many biolog-ical activities,which not only has a good protective effect on my-ocardial infarction,but could significantly alleviate myocardial ischemia-reperfusion injury.This article reviews the research progress of salvianolic acid B in cardiovascular diseases,and al-so includes discussion about the mechanisms of salvianolic acid B in the regulation of cardiovascular diseases,which may provide references for follow-up research and clinical treatment.