CAJ | 학술논문

目的：分析山区儿童胰岛素抵抗及其相关因素。方法在龙泉市山区选择1所中学和2所小学，随机抽取47个班级的10～15岁儿童2125人，测量体重、身高、腰围、血压以及血糖（FBG）、血清胰岛素（FINS）、甘油三酯（TG）、高密度脂蛋白（HDL －C）和总胆固醇（TC）等指标，并用计算所得的胰岛素抵抗指数（HOMA －IR）的75％分位数定义有无胰岛素抵抗（IR）。用多因素分析与 IR 有关的影响因素。结果HOMA －IR 第75百分位为2.59。单因素分析，除年龄、性别外，HDL －C、TG、nonHDL －C、BMI、WC、SBP、DBP、FPG 与 HOMA －IR 的相关系数均有统计学意义（P ＜0.05）；多因素 Logistic 回归分析对胰岛素抵抗（IR）具有显著影响的指标（OR 值，95％ CI）依次有 WC （1.07，1.06～1.09）、FPG （2.29，1.78～2.94）、HDL －C （0.34，0.21～0.56）和 TG （1.43，1.14～1.78）。结论WC、FPG 和 TG 可能是山区肥胖儿童胰岛素抵抗的危险因素，HDL －C 可能为保护因素。
목적：분석산구인동이도소저항급기상관인소。방법재룡천시산구선택1소중학화2소소학，수궤추취47개반급적10～15세인동2125인，측량체중、신고、요위、혈압이급혈당（FBG）、혈청이도소（FINS）、감유삼지（TG）、고밀도지단백（HDL －C）화총담고순（TC）등지표，병용계산소득적이도소저항지수（HOMA －IR）적75％분위수정의유무이도소저항（IR）。용다인소분석여 IR 유관적영향인소。결과HOMA －IR 제75백분위위2.59。단인소분석，제년령、성별외，HDL －C、TG、nonHDL －C、BMI、WC、SBP、DBP、FPG 여 HOMA －IR 적상관계수균유통계학의의（P ＜0.05）；다인소 Logistic 회귀분석대이도소저항（IR）구유현저영향적지표（OR 치，95％ CI）의차유 WC （1.07，1.06～1.09）、FPG （2.29，1.78～2.94）、HDL －C （0.34，0.21～0.56）화 TG （1.43，1.14～1.78）。결론WC、FPG 화 TG 가능시산구비반인동이도소저항적위험인소，HDL －C 가능위보호인소。
Objective To explore the influencing factors of insulin resistance among children in the mountainous area. Methods One middle school and 2 primary schools in Longquan city were randomly selected,47 classes of schoolchildren aged 1 0 -1 5 years were selected.Weight,height,waist circumstance (WC),blood pressure,blood glucose (FBG), serum insulin (FINS),triglycerides (TG),high -density lipoprotein (HDL -C)and total cholesterol (TC)were determined.Influencing factors of insulin resistance were analyzed by univariate and multiple logistic regression analysis. Results A total of 2 1 25 students were enrolled in this study.The 75th percentile of HOMA -IR was 2.59 respectively. The univariate analysis showed that HOMA -IR was significantly associated with HDL -C,TG,non HDL -C,BMI,WC, SBP,DBP and FPG (P <0.05).The multiple logistic regression analysis showed that WC (OR =1 .07,95%CI =1 .06 -1 .09),FPG (OR =2.29,95%CI =1 .78 -2.94),HDL -C (OR =0.34,95%CI =0.21 -0.56)and TG (OR =1 .43, 95%CI =1 .1 4 -1 .78)were the risk factors of insulin resistance.Conclusion WC,FPG,TG may be the risk factors of insulin resistance among children in the mountainous area,while HDL -C is the protective factor.