CAJ | 학술논문

目的：探讨雷珠单抗联合视网膜激光治疗视网膜中央静脉阻塞所致黄斑水肿的临床疗效。方法选取潍坊医学院附属医院2013年7月至2014年2月37例视网膜中央静脉阻塞患者,按不同治疗方法分为两组,对照组行单纯视网膜激光治疗；观察组玻璃体腔注射1次雷珠单抗0.05mL,7d 后行视网膜激光治疗。治疗前及治疗后1~6个月内行视力、眼底荧光血管造影、光学相干断层扫描检查,对比治疗前后患者上述检查指标变化情况。结果联合治疗优于单纯视网膜激光治疗视网膜静脉中央阻塞继发黄斑水肿,黄斑中心视网膜厚度明显减少(t =2.483,P <0.05)。结论玻璃体注射雷珠单抗联合视网膜激光治疗视网膜中央静脉阻塞所致黄斑水肿可快速、稳定地提高患者的视力。
목적：탐토뢰주단항연합시망막격광치료시망막중앙정맥조새소치황반수종적림상료효。방법선취유방의학원부속의원2013년7월지2014년2월37례시망막중앙정맥조새환자,안불동치료방법분위량조,대조조행단순시망막격광치료；관찰조파리체강주사1차뢰주단항0.05mL,7d 후행시망막격광치료。치료전급치료후1~6개월내행시력、안저형광혈관조영、광학상간단층소묘검사,대비치료전후환자상술검사지표변화정황。결과연합치료우우단순시망막격광치료시망막정맥중앙조새계발황반수종,황반중심시망막후도명현감소(t =2.483,P <0.05)。결론파리체주사뢰주단항연합시망막격광치료시망막중앙정맥조새소치황반수종가쾌속、은정지제고환자적시력。
Objective To investigate the effect of ranibizumab combined with retinal laser treat-ment of central retinal vein obstruction caused by the clinical efficacy of macular edema.Methods A total of 37 cases of patients with central retinal vein occlusion in the Affiliated Hospital of Wei-fang Medical College from July 2013 to February 2014 were selected,and divided into two groups according to different methods of treatment.Control group underwent retinal laser treatment, while observation group performed intravitreal injection of ranibizumab,0.05mL,1 time,retinal laser treatment performed after 7 days.Before treatment and from one to six months after treat-ment,visual acuity,fundus fluorescein angiography,optical coherence tomography were checked and compared before and after treatment.Results The combined therapy was better than the simple retinal laser treatment of macular edema caused by retinal vein central obstruction,macu-lar retinal thickness was significantly reduced(t = 2.483,P < 0.05 ).Conclusion Ranibizumab combined with retinal laser treatment in the treatment of macular edema caused by central retinal vein occlusion is fast,steadily improving the vision of patients.