中国药理学通报
中國藥理學通報
중국약이학통보
CHINESE PHARMACOLOGICAL BULLETIN
2015年
4期
461-464
,共4页
内质网应激%肿瘤耐药%UPR%ERS%凋亡抑制%自噬
內質網應激%腫瘤耐藥%UPR%ERS%凋亡抑製%自噬
내질망응격%종류내약%UPR%ERS%조망억제%자서
endoplasmic reticulum stress%cancer drug resist-ance%UPR%ERS%apoptotic suppression%autophagy
内质网是真核细胞内一种重要的细胞器,当细胞低氧、糖类供应不足或有化学药物处理时均可引发内质网应激(endoplasmic reticulum stress,ERS)。目前研究表明,内质网应激可激活多条通路,其中以未折叠蛋白反应(unfolded pro-tein response,UPR)通路研究最为广泛。UPR 通路激活后,可参与调控肿瘤细胞耐药。其中,参与的机制涉及 DNA 损伤修复、凋亡抑制、自噬等。
內質網是真覈細胞內一種重要的細胞器,噹細胞低氧、糖類供應不足或有化學藥物處理時均可引髮內質網應激(endoplasmic reticulum stress,ERS)。目前研究錶明,內質網應激可激活多條通路,其中以未摺疊蛋白反應(unfolded pro-tein response,UPR)通路研究最為廣汎。UPR 通路激活後,可參與調控腫瘤細胞耐藥。其中,參與的機製涉及 DNA 損傷脩複、凋亡抑製、自噬等。
내질망시진핵세포내일충중요적세포기,당세포저양、당류공응불족혹유화학약물처리시균가인발내질망응격(endoplasmic reticulum stress,ERS)。목전연구표명,내질망응격가격활다조통로,기중이미절첩단백반응(unfolded pro-tein response,UPR)통로연구최위엄범。UPR 통로격활후,가삼여조공종류세포내약。기중,삼여적궤제섭급 DNA 손상수복、조망억제、자서등。
Endoplasmic reticulum is an important organelle in eu-karyotic cells.Endoplasmic reticulum stress (ERS)is usually triggered under cell hypoxia,carbohydrate undersupply or medi-cal treatment.Now,present studies show that ERS could activate several cell signal pathways and the UPR pathway is most widely researched.When UPR activates cell signal pathway,it can reg-ulate cancer drug resistance by involving with DNA damage re-pair,apoptotic suppression and autophagy.