CAJ | 학술논문

骨组织中存在局部肾素－血管紧张素系统（RAS）。RAS 组分及其活性肽血管紧张素Ⅱ（Ang Ⅱ）直接参与调控骨代谢的病理生理进程。成骨细胞和破骨细胞都有 Ang Ⅱ的受体表达，这些受体介导了 Ang Ⅱ调控骨代谢的作用。该文回顾了经典 RAS 途径，探讨了组织 RAS 致局部组织病变的作用，并对 RAS 活性肽 Ang Ⅱ调控成骨细胞的靶基因、胞内信号通路、Ang Ⅱ通过成骨细胞间接调控破骨细胞功能、Ang Ⅱ受体在骨代谢调控中的交互作用进行了重点阐述。
골조직중존재국부신소－혈관긴장소계통（RAS）。RAS 조분급기활성태혈관긴장소Ⅱ（Ang Ⅱ）직접삼여조공골대사적병리생리진정。성골세포화파골세포도유 Ang Ⅱ적수체표체，저사수체개도료 Ang Ⅱ조공골대사적작용。해문회고료경전 RAS 도경，탐토료조직 RAS 치국부조직병변적작용，병대 RAS 활성태 Ang Ⅱ조공성골세포적파기인、포내신호통로、Ang Ⅱ통과성골세포간접조공파골세포공능、Ang Ⅱ수체재골대사조공중적교호작용진행료중점천술。
The renin-angiotensin system exists locally in bone tissue.The RAS components and the active peptide angiotensinⅡ (Ang Ⅱ)within RAS are directly involved in the pathophysi-ological process of regulating bone metabolism.Ang Ⅱ exerts the effects via its receptors expressed in osteoblasts and osteoclasts. This paper reviewed the pathways of classical RAS,explained the tissue RAS-induced tissue injuries,and especially elaborated the regulation of RAS active peptide Ang Ⅱ on target genes and in-tracellular signaling pathways in osteoblasts,the action of Ang Ⅱon osteoclastic function via acting on osteoblasts,and the inter-action of Ang Ⅱ receptors involved in the modulation on bone metabolism.