CAJ | 학술논문

目的：探讨 N 末端 B 型钠尿肽前体（NT －proBNP）水平与孕妇是否合并心脏病的相关性。方法选取妊娠合并心脏病孕妇74例和同期正常妊娠孕妇80人，两组分别检测晚妊期 NT －proBNP 血浆浓度并作比较，其中正常妊娠孕妇组还检测早妊期 NT －proBNP 血浆浓度，分别与该组晚妊期结果比较，同时对妊娠合并心脏病孕妇作心功能分级，并与晚妊期血浆 NT －proBNP 水平作关联性分析。结果妊娠合并心脏病孕妇 NT －proBNP 血浆浓度（中位数为352.50 pg／mL，浓度范围为84.00～3806.00 pg／mL）明显高于正常妊娠孕妇晚妊期（中位数为58.00 pg／mL，浓度范围为26.00～164.00 pg／mL）（P ＜0.01），其心功能分级越高，NT －proBNP 血浆浓度水平也越高（P ＜0.01）；正常妊娠孕妇的晚妊期 NT －proBNP 血浆浓度高于早妊期（中位数为49.00 pg／mL，浓度范围为20.00～178.00 pg／mL）（P ＜0.01）。结论NT －proBNP 血浆浓度水平在评价合并心脏病孕妇心功能受损程度有重要的临床应用价值，妊娠对正常孕妇心功能有一定的影响。
목적：탐토 N 말단 B 형납뇨태전체（NT －proBNP）수평여잉부시부합병심장병적상관성。방법선취임신합병심장병잉부74례화동기정상임신잉부80인，량조분별검측만임기 NT －proBNP 혈장농도병작비교，기중정상임신잉부조환검측조임기 NT －proBNP 혈장농도，분별여해조만임기결과비교，동시대임신합병심장병잉부작심공능분급，병여만임기혈장 NT －proBNP 수평작관련성분석。결과임신합병심장병잉부 NT －proBNP 혈장농도（중위수위352.50 pg／mL，농도범위위84.00～3806.00 pg／mL）명현고우정상임신잉부만임기（중위수위58.00 pg／mL，농도범위위26.00～164.00 pg／mL）（P ＜0.01），기심공능분급월고，NT －proBNP 혈장농도수평야월고（P ＜0.01）；정상임신잉부적만임기 NT －proBNP 혈장농도고우조임기（중위수위49.00 pg／mL，농도범위위20.00～178.00 pg／mL）（P ＜0.01）。결론NT －proBNP 혈장농도수평재평개합병심장병잉부심공능수손정도유중요적림상응용개치，임신대정상잉부심공능유일정적영향。
Objective To explore the relationship between the cardiac function of pregnant women with cardiac disease and the level of N -terminal pro -B -type natriuretic peptide (NT -pro -BNP).Methods A total of 74 pregnant women with cardiac disease and 80 healthy pregnant women were enrolled in the study and the NT -pro -BNP was detected and compared.The concentrations of NT -pro -BNP in different trimester were compared among the healthy pregnant women, and the correlation between the cardiac function of pregnant women with cardiac disease and the level of NT -pro -BNP were analyzed.Results The median of concentrations of plasma NT -pro -BNP in pregnant women with cardiac disease was 352.50 pg/mL,which was significantly higher than that in healthy pregnant women 58.00 pg/mL(P <0.01 ).The cardiac function was positively correlated with the level of NT -pro -BNP (P <0.01 ).The concentration of plasma NT -pro -BNP during the late trimester(49.00 pg/mL)was significantly higher than that of the early trimester(49.00 pg/mL) among the healthy pregnant women (P <0.01 ).Conclusion It is of great clinical value for the concentration of plasma NT-pro -BNP in evaluating the cardiac function of pregnant women with cardiac disease,and the pregnancy may influence the cardiac function.