CAJ | 학술논문

目的：探讨重楼皂苷对四氯化碳（CCl4）诱导的肝纤维化大鼠肝功能以及肝纤维化标志物的影响及其相关性。方法：SD大鼠随机分为正常组、模型组，重楼皂苷低、中、高剂量组，复方鳖甲软肝片组、秋水仙碱组。除正常组外，其余各组采用CCl4致肝纤维化造模。第7周后，正常组灌胃生理盐水，其余各组灌胃相应药物，1次/d。末次给药后，禁食8 h，处死动物取血，ELISA法检测大鼠血清ALT、AST、肝纤四项指标（CⅣ、PCⅢ、LN、HA）含量以及肝组织HYP水平。结果：与模型组比较，重楼皂苷各剂量组大鼠血清ALT、AST和肝纤四项指标含量、肝组织HYP含量降低（P＜0.05，P＜0.01）。ALT、AST含量与CⅣ、PCⅢ、LN、HA含量具有相关性（P＜0.05，P＜0.01）。结论：重楼皂苷具有一定的保肝降酶作用，能减轻肝纤维化程度。
목적：탐토중루조감대사록화탄（CCl4）유도적간섬유화대서간공능이급간섬유화표지물적영향급기상관성。방법：SD대서수궤분위정상조、모형조，중루조감저、중、고제량조，복방별갑연간편조、추수선감조。제정상조외，기여각조채용CCl4치간섬유화조모。제7주후，정상조관위생리염수，기여각조관위상응약물，1차/d。말차급약후，금식8 h，처사동물취혈，ELISA법검측대서혈청ALT、AST、간섬사항지표（CⅣ、PCⅢ、LN、HA）함량이급간조직HYP수평。결과：여모형조비교，중루조감각제량조대서혈청ALT、AST화간섬사항지표함량、간조직HYP함량강저（P＜0.05，P＜0.01）。ALT、AST함량여CⅣ、PCⅢ、LN、HA함량구유상관성（P＜0.05，P＜0.01）。결론：중루조감구유일정적보간강매작용，능감경간섬유화정도。
Objective:To study the protective effect of Chonglou saponin on liver function and hepatic fibrosis markers of hepatic fibrosis rats induced by carbon tetrachloride. Method:SD rats were randomly divided into normal group,model group,Fufang Biejia Ruangan tablets group,colchicine group,Chonglou saponin groups of high,medium and low dosage. After administration,the levels of ALT,AST,HA,LN,CⅣ,PCⅢ in serum and HYP in liver tissure were measured by ELISA assay. Results:Compared with model group,the levels of ALT,AST,liver fibrosis four indicators in serum and HYP in liver tissue of Chonglou saponin groups were reduced(P<0.05,P<0.01). The contents of ALT,AST and HYP were asso-ciated with the contents of HA,LN,CⅣ,PCⅢ(P<0.05,P<0.01). Conclusion:Chonglou saponin has certain effect of protect-ing liver and reducing enzyme,and could reduce the degree of liver fibrosis.