世界最新医学信息文摘(连续型电子期刊)
世界最新醫學信息文摘(連續型電子期刊)
세계최신의학신식문적(련속형전자기간)
World Latest Medicine Information
2015年
10期
3-4
,共2页
许慧洁%邓丽娜%谢静燕%张英%白玲
許慧潔%鄧麗娜%謝靜燕%張英%白玲
허혜길%산려나%사정연%장영%백령
子宫内膜异位症%疾病遗传易感性%白细胞介素10%多态性,限制性片段长度
子宮內膜異位癥%疾病遺傳易感性%白細胞介素10%多態性,限製性片段長度
자궁내막이위증%질병유전역감성%백세포개소10%다태성,한제성편단장도
Endometrium ectopia%Genetic susceptibility to disease%Interleukin 10%Polymorphism,Restriction fragment length
目的:子宫内膜异位症患者白细胞介素10的启动子区域转录起始位点C-A多态性,探讨调控EMs易感性之间的机制。方法:应用聚合酶链反应一限制性片段长度多态性检测EMs组214例和正常对照组160名健康人的启动子区域转录起始位点上游的第1082位点G-A、819位点C-T及592位点C-A碱基转换,采用SPSSll.0软件包统计分析各位点的基因型分布和等位基因频率。结果:IL-10-1082位点的多态性在EMs组与对照组的基因频率统计差异性(x2=0.01,P=0.919),IL-10-819和-592基因型在EMs组分布与对照组差异无统计学意义(x2=5.87,P=0.053)。但患者组IL-10-819的CT及-592的CA基因型频率较对照组增高,差异有统计学意义(校正后OR=1.88,x2=5.24),-819和-592位点的C等位基因与EMs发病风险具有显著相关性(OR=1.42,P=0.028)。结论:IL-10-592C及-819C等位基因与IL-10高表达相关,并与EMs的易感性具相关性,也与EMs的发病风险相关。
目的:子宮內膜異位癥患者白細胞介素10的啟動子區域轉錄起始位點C-A多態性,探討調控EMs易感性之間的機製。方法:應用聚閤酶鏈反應一限製性片段長度多態性檢測EMs組214例和正常對照組160名健康人的啟動子區域轉錄起始位點上遊的第1082位點G-A、819位點C-T及592位點C-A堿基轉換,採用SPSSll.0軟件包統計分析各位點的基因型分佈和等位基因頻率。結果:IL-10-1082位點的多態性在EMs組與對照組的基因頻率統計差異性(x2=0.01,P=0.919),IL-10-819和-592基因型在EMs組分佈與對照組差異無統計學意義(x2=5.87,P=0.053)。但患者組IL-10-819的CT及-592的CA基因型頻率較對照組增高,差異有統計學意義(校正後OR=1.88,x2=5.24),-819和-592位點的C等位基因與EMs髮病風險具有顯著相關性(OR=1.42,P=0.028)。結論:IL-10-592C及-819C等位基因與IL-10高錶達相關,併與EMs的易感性具相關性,也與EMs的髮病風險相關。
목적:자궁내막이위증환자백세포개소10적계동자구역전록기시위점C-A다태성,탐토조공EMs역감성지간적궤제。방법:응용취합매련반응일한제성편단장도다태성검측EMs조214례화정상대조조160명건강인적계동자구역전록기시위점상유적제1082위점G-A、819위점C-T급592위점C-A감기전환,채용SPSSll.0연건포통계분석각위점적기인형분포화등위기인빈솔。결과:IL-10-1082위점적다태성재EMs조여대조조적기인빈솔통계차이성(x2=0.01,P=0.919),IL-10-819화-592기인형재EMs조분포여대조조차이무통계학의의(x2=5.87,P=0.053)。단환자조IL-10-819적CT급-592적CA기인형빈솔교대조조증고,차이유통계학의의(교정후OR=1.88,x2=5.24),-819화-592위점적C등위기인여EMs발병풍험구유현저상관성(OR=1.42,P=0.028)。결론:IL-10-592C급-819C등위기인여IL-10고표체상관,병여EMs적역감성구상관성,야여EMs적발병풍험상관。
Objective: Ectopic endometrium of patients with interleukin-10 promoter region polymorphism of transcription start sites in C-A, explore the mechanism of controlling susceptibility between EMs. Method: polymerase chain reaction-restriction fragment length polymorphism assay EMs group of 214 patients and normal control group of 160 healthy people upstream of transcription start sites in the promoter region of 1082th G-A, 819 points of C-T C-A base conversion and 592 points, using SPSSll. 0 statistical analysis packages you point the genotype and allele frequency. Results:IL-10-1082 loci polymorphic in the EMs statistical difference of gene frequency of the Group and the control group (x2=0. 01,P=0. 919) , IL-10-819 and EMs-592 genotype distribution group and control group differences was not statistically significant (x2=5. 87,P=0. 053) . Group IL-10-819-592 CA and CT in patients with genotype frequencies higher than the control group, there was a statistically significant dif-ference (adjusted OR=1. 88,x2=5. 24) , c-592 and-819 sites risk allele with the EMs has significant correlation (OR=1. 42,P=0. 028) . Conclusion:the IL-10-592C and-819C alleles associated with the expression of IL-10 and correlation between sus-ceptibility and EMs, also associated with a risk of EMs.