CAJ | 학술논문

目的：观察针刺风池配合经外奇穴对高血压患者TNF-a、ET的调节作用。方法收集150例高血压患者,按照1：1将患者随机分为两组。对照组75例患者行针刺治疗,取双侧风池穴；治疗组75例在针刺双侧风池穴的基础上加经外奇穴针刺治疗,每次留针30 min,每隔10 min捻针1次。每日1次,治疗2星期为1个疗程。结果两组治疗期间检测患者TNF-a和ET含量,治疗组75例患者TNF-a及ET含量均显著降低(P＜0.05)；对照组TNF-a和ET也有所降低,但变化量不具有统计学意义(P＞0.05)。治疗组1个疗程后TNF-a、ET含量较治疗前显著降低(P＜0.05)；对照组治疗前后TNF-a和ET含量的变化无显著性差异(P＞0.05)；治疗组与对照组比较差异有统计学意义(P＜0.05)。两组不同程度高血压患者血清TNF-a、ET含量比较差异具有统计学意义(P＜0.01)。结果表明针刺风池穴配合经外奇穴患者血清TNF-a和ET含量低于针刺风池穴患者,即经外奇穴配合风池针刺在TNF-a和ET含量调节方面起着重要的作用。结论针刺风池配合经外奇穴对高血压患者TNF-a、ET的调节作用优于单纯针刺风池治疗。
목적：관찰침자풍지배합경외기혈대고혈압환자TNF-a、ET적조절작용。방법수집150례고혈압환자,안조1：1장환자수궤분위량조。대조조75례환자행침자치료,취쌍측풍지혈；치료조75례재침자쌍측풍지혈적기출상가경외기혈침자치료,매차류침30 min,매격10 min념침1차。매일1차,치료2성기위1개료정。결과량조치료기간검측환자TNF-a화ET함량,치료조75례환자TNF-a급ET함량균현저강저(P＜0.05)；대조조TNF-a화ET야유소강저,단변화량불구유통계학의의(P＞0.05)。치료조1개료정후TNF-a、ET함량교치료전현저강저(P＜0.05)；대조조치료전후TNF-a화ET함량적변화무현저성차이(P＞0.05)；치료조여대조조비교차이유통계학의의(P＜0.05)。량조불동정도고혈압환자혈청TNF-a、ET함량비교차이구유통계학의의(P＜0.01)。결과표명침자풍지혈배합경외기혈환자혈청TNF-a화ET함량저우침자풍지혈환자,즉경외기혈배합풍지침자재TNF-a화ET함량조절방면기착중요적작용。결론침자풍지배합경외기혈대고혈압환자TNF-a、ET적조절작용우우단순침자풍지치료。
ObjectiveToobserve the regulating effect of acupuncture at Fengchi (GB20) and extraordinary points on tumor necrosis factor (TNF)-aand endothelin (ET) in hypertension.MethodTotally 150 patients with hypertension were randomized into two groups at a ratio of 1:1.In the control group, 75 subjects were intervened by acupuncture at bilateral Fengchi; in the treatment group, 75 subjects were intervened by acupuncture at bilateral Fengchi plus extraordinary points. The needles were manipulated once every 10 min duringthe 30-min session. The treatment was given once per day, 2 weeks as a treatment course. ResultDuring the intervention, the TNF-aand ET contents were decreased significantly in the treatment group (P<0.05); the TNF-aand ET contents were also decreased in the control group but without statistical significance (P>0.05). After 1 treatment course, the TNF-aand ET contents were decreased significantly in the treatment group (P<0.05); the TNF-aand ET contents were insignificantly decreased in the control group (P>0.05); there was a significant difference in comparing the TNF-aand ET contents between the two groups (P<0.05). There were also significant differences in comparing the TNF-aand ET contents inhypertension of various degrees between the two groups (P<0.01). The results showed that the TNF-aand ET contents in patients intervened by acupuncture at Fengchiand extraordinary points were lower than that in those intervened by acupuncture at Fengchialone, i.e. combination of Fengchi and extraordinary points produces a significant effect on regulating TNF-aand ET contents.Conclusion Acupuncture at Fengchi and extraordinary points can produce a more significant effect than acupuncture at Fengchi alone on regulating TNF-aand ET in patients with hypertension.