北方药学
北方藥學
북방약학
JOURNAL OF NORTH PHARMACY
2015年
4期
50-51,52
,共3页
两性霉素B%真菌感染%疗效%不良反应
兩性黴素B%真菌感染%療效%不良反應
량성매소B%진균감염%료효%불량반응
Amphotericin B%Fungal infection%Efficacy%Adverse drug reactions
目的：回顾性评价两性霉素B治疗真菌感染的疗效及药物不良反应（ADR）。方法：收集2011年1月～2014年6月我院应用两性霉素B治疗真菌感染的病例，以痊愈、显效、进步、无效4种评价标准对其疗效进行评价，并对不良反应进行分析研究。结果：共纳入患者131例，痊愈24例，显效77例，好转9例，无效21例，总体有效率为77.10%；110例患者出现不同程度的不良反应，其中6例（4.58%）因反应严重需要更换用药，其余患者对症处理后不影响治疗。结论：两性霉素B治疗真菌感染的疗效显著，药物不良反应在可控制范围内。
目的：迴顧性評價兩性黴素B治療真菌感染的療效及藥物不良反應（ADR）。方法：收集2011年1月～2014年6月我院應用兩性黴素B治療真菌感染的病例，以痊愈、顯效、進步、無效4種評價標準對其療效進行評價，併對不良反應進行分析研究。結果：共納入患者131例，痊愈24例，顯效77例，好轉9例，無效21例，總體有效率為77.10%；110例患者齣現不同程度的不良反應，其中6例（4.58%）因反應嚴重需要更換用藥，其餘患者對癥處理後不影響治療。結論：兩性黴素B治療真菌感染的療效顯著，藥物不良反應在可控製範圍內。
목적：회고성평개량성매소B치료진균감염적료효급약물불량반응（ADR）。방법：수집2011년1월～2014년6월아원응용량성매소B치료진균감염적병례，이전유、현효、진보、무효4충평개표준대기료효진행평개，병대불량반응진행분석연구。결과：공납입환자131례，전유24례，현효77례，호전9례，무효21례，총체유효솔위77.10%；110례환자출현불동정도적불량반응，기중6례（4.58%）인반응엄중수요경환용약，기여환자대증처리후불영향치료。결론：량성매소B치료진균감염적료효현저，약물불량반응재가공제범위내。
Objective:To retrospectively assess the efficacy and adverse drug reactions of domestic amphotericin B for therapy of fungal infections. Methods:Fungal infections received amphotericin B treatment from January 2011 to June 2014 included in this research. Outcomes were described as cure, improvement, or unresponsiveness, and adverse drug reactions (ADR) were assessed as well. Results:In 131 patients, 24 patients were cured, while 77 improved and 9 were unresponsive to the therapy. There were 110 patients developed ADR, among them 6 cases (4.58%) had to replaced treatment plan because of?the severe ADR,the rest patients could stand the therapy after symptomatic treatment. Conclusions:Domestic amphotericin B could effectively treat the fungal infections, and the ADRs were acceptable.
