临床医学工程
臨床醫學工程
림상의학공정
CLINICAL MEDICAL ENGINEERING
2015年
4期
453-454
,共2页
张志强%钟继生%陈翔%林小兵
張誌彊%鐘繼生%陳翔%林小兵
장지강%종계생%진상%림소병
围产期孕妇%B族链球菌%药敏分析%妊娠结局%新生儿感染
圍產期孕婦%B族鏈毬菌%藥敏分析%妊娠結跼%新生兒感染
위산기잉부%B족련구균%약민분석%임신결국%신생인감염
Perinatal pregnant women%Group B streptococcus%Sensitivity analysis%Pregnancy outcome%Neonatal infection
目的：分析围产期P妇GBS感染状况及其药敏特点，评估GBS感染对妊娠结局的影响。方法收集2013年9月至2014年9月期间在我院进行围产保健的7000例P妇的临床资料，应用荧光定量PCR进行GBS检测，并对分离出的GBS进行药敏实验，分析GBS感染阳性与阴性对妊娠结局的影响以及GBS阳性P妇药敏及耐药性情况。结果7000例围产期P妇GBS阳性率为10.4%(728/7000)。 GBS阳性P妇胎膜早破和宫内感染发生率分别为35.0%、14.7%，均高于GBS阴性P妇的21.0%和5.2%，差异具有统计学意义(P<0.01)； GBS阳性P妇早产和新生儿感染发生率略低于GBS阴性P妇，但差异无统计学意义(P>0.05)。728例围产期P妇GBS感染阳性者对青霉素、氨苄青霉素、万古霉素的敏感率均为100.0%，对阿奇霉素、红霉素、克林霉素和左氧氟沙星的敏感率分别是44.7%、34.6%、58.6%、70.0%。结论对围产期P妇进行荧光定量PCR检测GBS具有重要意义。掌握GBS感染阳性的药敏特点有利于积极预防和治疗GBS感染，并能降低妊娠不良结局的发生率。
目的：分析圍產期P婦GBS感染狀況及其藥敏特點，評估GBS感染對妊娠結跼的影響。方法收集2013年9月至2014年9月期間在我院進行圍產保健的7000例P婦的臨床資料，應用熒光定量PCR進行GBS檢測，併對分離齣的GBS進行藥敏實驗，分析GBS感染暘性與陰性對妊娠結跼的影響以及GBS暘性P婦藥敏及耐藥性情況。結果7000例圍產期P婦GBS暘性率為10.4%(728/7000)。 GBS暘性P婦胎膜早破和宮內感染髮生率分彆為35.0%、14.7%，均高于GBS陰性P婦的21.0%和5.2%，差異具有統計學意義(P<0.01)； GBS暘性P婦早產和新生兒感染髮生率略低于GBS陰性P婦，但差異無統計學意義(P>0.05)。728例圍產期P婦GBS感染暘性者對青黴素、氨芐青黴素、萬古黴素的敏感率均為100.0%，對阿奇黴素、紅黴素、剋林黴素和左氧氟沙星的敏感率分彆是44.7%、34.6%、58.6%、70.0%。結論對圍產期P婦進行熒光定量PCR檢測GBS具有重要意義。掌握GBS感染暘性的藥敏特點有利于積極預防和治療GBS感染，併能降低妊娠不良結跼的髮生率。
목적：분석위산기P부GBS감염상황급기약민특점，평고GBS감염대임신결국적영향。방법수집2013년9월지2014년9월기간재아원진행위산보건적7000례P부적림상자료，응용형광정량PCR진행GBS검측，병대분리출적GBS진행약민실험，분석GBS감염양성여음성대임신결국적영향이급GBS양성P부약민급내약성정황。결과7000례위산기P부GBS양성솔위10.4%(728/7000)。 GBS양성P부태막조파화궁내감염발생솔분별위35.0%、14.7%，균고우GBS음성P부적21.0%화5.2%，차이구유통계학의의(P<0.01)； GBS양성P부조산화신생인감염발생솔략저우GBS음성P부，단차이무통계학의의(P>0.05)。728례위산기P부GBS감염양성자대청매소、안변청매소、만고매소적민감솔균위100.0%，대아기매소、홍매소、극림매소화좌양불사성적민감솔분별시44.7%、34.6%、58.6%、70.0%。결론대위산기P부진행형광정량PCR검측GBS구유중요의의。장악GBS감염양성적약민특점유리우적겁예방화치료GBS감염，병능강저임신불량결국적발생솔。
Objective To analyze the infection conditions and susceptibility characteristics of GBS in perinatal pregnant women, and to evaluate the impact of GBS infection on pregnancy outcome. Methods The clinical data of 7 000 cases of pregnant women received perinatal health care in our hospital from September 2013 to September 2014 were collected. GBS was detected by fluorescence quantitative PCR, and isolated GBS was given susceptibility experiment. The impact of positive and negative GBS on pregnancy outcome was analyzed, the conditions of susceptibility and tolerance in GBS positive women were also analyzed. Results The GBS positive rate of 7 000 perinatal pregnant women was 10.4%(728/7 000). The incidence of PROM and intrauterine infection of GBS positive pregnant women were 35.0%and 14.7%, higher than 21.0%and 5.2%of GBS negative women, with statistical difference (P <0.01); the premature birth and neonatal infection of GBS positive women were slightly lower than GBS negative women, but without statistical difference (P>0.05). The sensitivity rate of penicillin, ampicillin and vancomycin in GBS infection-positive pregnant women (728 cases) were all 100.0%, the sensitivity rate of azithromycin, erythromycin, clindamycin and levofloxacin were 44.7%, 34.6%, 58.6%and 70.0%respectively. Conclusions Fluorescence quantitative PCR has significance in detecting GBS for perinatal pregnant women. The grasp of susceptibility characteristics of GBS infection is beneficial to actively prevent and treat GBS infection, and also reduce the incidence of adverse pregnancy outcome.
