临床医学工程
臨床醫學工程
림상의학공정
CLINICAL MEDICAL ENGINEERING
2015年
4期
473-474,477
,共3页
胃食管反流%兰索拉唑%莫沙比利%临床效果
胃食管反流%蘭索拉唑%莫沙比利%臨床效果
위식관반류%란색랍서%막사비리%림상효과
Gastroesophageal reflux%Lansoprazole%Mosapride%Clinical effect
目的：探析胃食管反流患者采用兰索拉唑联合莫沙比利治疗的临床效果。方法选取我院2012年4月至2014年4月收治的胃食管反流患者126例为研究对象，按照治疗方法的不同将患者分为观察组和对照组各63例。对照组患者给予莫沙比利治疗，观察组患者给予兰索拉唑联合莫沙比利治疗。六周后，观察患者的临床疗效及不良反应情况，同时评估患者食管黏膜的变化情况。结果治疗后，两组患者的病情均有改善，但观察组治疗总有效率明显高于对照组(90.5%vs 76.2%)，差异有统计学意义(P<0.05)。观察组胃镜检查的总有效率显著高于对照组(85.7%vs 69.8%)，差异有统计学意义(P<0.05)。两组患者用药期间均未出现明显的肝肾功能异常，观察组不良反应发生率与对照组相比差异不显著(12.7%vs 15.9%)，无统计学意义(P>0.05)。结论胃食管反流患者实施兰索拉唑联合莫沙比利治疗，可有效缓解患者的临床症状，提高患者的生活质量，安全有效，值得推广应用。
目的：探析胃食管反流患者採用蘭索拉唑聯閤莫沙比利治療的臨床效果。方法選取我院2012年4月至2014年4月收治的胃食管反流患者126例為研究對象，按照治療方法的不同將患者分為觀察組和對照組各63例。對照組患者給予莫沙比利治療，觀察組患者給予蘭索拉唑聯閤莫沙比利治療。六週後，觀察患者的臨床療效及不良反應情況，同時評估患者食管黏膜的變化情況。結果治療後，兩組患者的病情均有改善，但觀察組治療總有效率明顯高于對照組(90.5%vs 76.2%)，差異有統計學意義(P<0.05)。觀察組胃鏡檢查的總有效率顯著高于對照組(85.7%vs 69.8%)，差異有統計學意義(P<0.05)。兩組患者用藥期間均未齣現明顯的肝腎功能異常，觀察組不良反應髮生率與對照組相比差異不顯著(12.7%vs 15.9%)，無統計學意義(P>0.05)。結論胃食管反流患者實施蘭索拉唑聯閤莫沙比利治療，可有效緩解患者的臨床癥狀，提高患者的生活質量，安全有效，值得推廣應用。
목적：탐석위식관반류환자채용란색랍서연합막사비리치료적림상효과。방법선취아원2012년4월지2014년4월수치적위식관반류환자126례위연구대상，안조치료방법적불동장환자분위관찰조화대조조각63례。대조조환자급여막사비리치료，관찰조환자급여란색랍서연합막사비리치료。륙주후，관찰환자적림상료효급불량반응정황，동시평고환자식관점막적변화정황。결과치료후，량조환자적병정균유개선，단관찰조치료총유효솔명현고우대조조(90.5%vs 76.2%)，차이유통계학의의(P<0.05)。관찰조위경검사적총유효솔현저고우대조조(85.7%vs 69.8%)，차이유통계학의의(P<0.05)。량조환자용약기간균미출현명현적간신공능이상，관찰조불량반응발생솔여대조조상비차이불현저(12.7%vs 15.9%)，무통계학의의(P>0.05)。결론위식관반류환자실시란색랍서연합막사비리치료，가유효완해환자적림상증상，제고환자적생활질량，안전유효，치득추엄응용。
Objective To analyze the clinical effect of lansoprazole combined with mosapride in the treatment of patients with gastroesophageal reflux. Methods 126 cases of patients with gastroesophageal reflux treated in our hospital from April 2012 to April 2014 were selected as research objects and randomly divided into observation group and control group according to different treatment method. The control group (63 cases) were given mosapride for treating, while the observation group (63 cases) received lansoprazole combined with mosapride therapy. After 6 weeks, the clinical effect and adverse reactions of two groups were observed, the changes of esophageal mucosa were evaluated. Results The clinical symptoms of the two groups were improved after treatment, but the total effective rate of observation group was significantly higher than that of control group (90.5%v s 76.2%), with statistical difference (P<0.05); the total efficient rate of gastroscopy in the observation group was significantly higher than that of the control group (85.7%v s 69.8%), the difference was statistically significant (P<0.05). The abnormalities of liver and renal function in the two groups were not found during treatment period, the incidence of adverse reactions of the two groups had no significant difference (12.7% vs 15.9%, P >0.05). Conclusions For patients with gastroesophageal reflux, lansoprazole combined with mosapride can effectively alleviate patients' clinical symptoms and improve patients' life quality, which is safe and effective, and deserves promotion.
