CAJ | 학술논문

目的：探究间歇性内分泌法治疗晚期前列腺癌的临床效果。方法回顾性分析2013年1月至2014年3月我院收治的56例晚期前列腺癌患者的临床资料，根据治疗方法的不同将患者分为对照组和实验组各28例，对照组患者给予持续性内分泌治疗，实验组患者给予间歇性内分泌治疗。比较两组患者的临床治疗效果、不良反应发生情况和五年生存率。结果两组的治疗总有效率(92.86%vs 85.71%)和5年生存率(78.57%vs 71.43%)相比差异不显著(P>0.05)，但实验组的显效率(57.14%)显著高于对照组(25.00%)，差异具有统计学意义(P <0.05)。两组骨质疏松和性欲降低等不良反应发生率相比差异不显著(P >0.05)，但实验组发热、贫血和食欲下降等不良反应发生率均显著低于对照组，差异具有统计学意义(P<0.05)。结论对于晚期前列腺癌患者，给予其间歇性内分泌治疗的效果好，能够显著提高患者的功能状态、生活质量，同时不良反应少，安全可靠，值得临床推广。
목적：탐구간헐성내분비법치료만기전렬선암적림상효과。방법회고성분석2013년1월지2014년3월아원수치적56례만기전렬선암환자적림상자료，근거치료방법적불동장환자분위대조조화실험조각28례，대조조환자급여지속성내분비치료，실험조환자급여간헐성내분비치료。비교량조환자적림상치료효과、불량반응발생정황화오년생존솔。결과량조적치료총유효솔(92.86%vs 85.71%)화5년생존솔(78.57%vs 71.43%)상비차이불현저(P>0.05)，단실험조적현효솔(57.14%)현저고우대조조(25.00%)，차이구유통계학의의(P <0.05)。량조골질소송화성욕강저등불량반응발생솔상비차이불현저(P >0.05)，단실험조발열、빈혈화식욕하강등불량반응발생솔균현저저우대조조，차이구유통계학의의(P<0.05)。결론대우만기전렬선암환자，급여기간헐성내분비치료적효과호，능구현저제고환자적공능상태、생활질량，동시불량반응소，안전가고，치득림상추엄。
Objective To explore the clinical effect of intermittent endocrine therapy on advanced prostate cancer. Methods Clinical data of 56 patients with advanced prostate cancer treated in our hospital from January 2013 to March 2014 were retrospectively analyzed. All patients were divided into control group (28 cases) and experimental group (28 cases) according to different treatment method. The control group was given continuous endocrine therapy, the experimental group was given intermittent endocrine therapy. The clinical effects, adverse reactions and five-year survival rate between the two groups were compared. Results The total effective rate (92.86%v s 85.71%) and five-year survival rate (78.57%vs 71.43%) of the two groups had no statistical difference (P>0.05), but the marked effective rate of the experimental group was significantly higher than that of the control group (57.14%vs 25.00%), with statistical difference (P <0.05). The incidence of osteoporosis and reduced sex drive between the two groups had no statistical difference (P>0.05), but the incidence of fever, anemia and appetite drops in the experimental group were significantly lower than those in the control group, with statistical difference (P<0. 05). Conclusions For patients with advanced prostate cancer, intermittent endocrine therapy has significant effect and can greatly improve the functions and life quality of patients, with fewer adverse reactions, which is safe and reliable and deserves clinical application.