CAJ | 학술논문

目的：探讨米非司酮、米索前列醇、丙酸睾酮联合应用在终止10~14周妊娠中的临床疗效。方法将120例拟终止妊娠的婚育年龄期妇女随机分为两组各60例。对照组给予米非司酮片及米索前列醇片，观察组在此基础上加用丙酸睾酮。比较两组的排胎成功率、排胎时间与阴道出血量。结果观察组完全排胎58例，不全排胎与排胎失败各1例，排胎成功率为96.7豫；对照组完全排胎44例，不全排胎13例，排胎失败3例，排胎成功率为73.3豫；两组排胎成功率相比差异显著(P<0.05)。观察组服药至排胎时间为(5.41±2.01)澡，腹痛至排胎时间为(3.15±1.21)澡，均显著短于对照组的(7.63±2.91)澡、(5.24±2.06)澡，差异具有统计学意义(P<0.05)；观察组阴道出血量为(48.63±12.84)皂蕴，明显少于对照组的(65.73±15.62)皂蕴，差异具有统计学意义(P<0.05)。结论采用米非司酮、米索前列醇、丙酸睾酮联合终止10~14周妊娠，可以提高排胎成功率，加快引产时间，缩短出血时间而减少出血量。
목적：탐토미비사동、미색전렬순、병산고동연합응용재종지10~14주임신중적림상료효。방법장120례의종지임신적혼육년령기부녀수궤분위량조각60례。대조조급여미비사동편급미색전렬순편，관찰조재차기출상가용병산고동。비교량조적배태성공솔、배태시간여음도출혈량。결과관찰조완전배태58례，불전배태여배태실패각1례，배태성공솔위96.7예；대조조완전배태44례，불전배태13례，배태실패3례，배태성공솔위73.3예；량조배태성공솔상비차이현저(P<0.05)。관찰조복약지배태시간위(5.41±2.01)조，복통지배태시간위(3.15±1.21)조，균현저단우대조조적(7.63±2.91)조、(5.24±2.06)조，차이구유통계학의의(P<0.05)；관찰조음도출혈량위(48.63±12.84)조온，명현소우대조조적(65.73±15.62)조온，차이구유통계학의의(P<0.05)。결론채용미비사동、미색전렬순、병산고동연합종지10~14주임신，가이제고배태성공솔，가쾌인산시간，축단출혈시간이감소출혈량。
Objective To explore the clinical effect of mifepristone, misoprostol and testosterone propionate on termination of pregnancy in 10 to 14 weeks. Methods 120 cases of married women in child-bearing age scheduled to terminate pregnancy were divided into two groups, with 60 cases in each group. The control group was given mifepristone and misoprostol tablets, the observation group was given testosterone propionate on this basis. The pregnancy termination rate, pregnancy termination time and vaginal bleeding of two groups were compared. Results The pregnancy termination rate of observation group was 96.7%, with successful pregnancy termination in 58 cases, incomplete termination in 1 case and failed termination in 1 case;the pregnancy termination rate of control group was 73.3%, with successful pregnancy termination in 44 cases, incomplete termination in 13 cases and failed termination in 3 cases;the pregnancy termination rate of two groups had statistically significant difference (P <0.05). The average time of observation group from taking medicine to pregnancy termination and from abdominal pain to pregnancy termination were (5.41±2.01) h and (3.15±1.21) h respectively, shorter than (7.63±2.91) h and (5.24±2.06) h of control group;the vaginal bleeding of observation group was (48.63±12.84) mL, less than (65.73±15.62) mL of control group, all the difference was statistical (P<0.05). Conclusions For the termination of pregnancy in 10 to14 weeks, the application of mifepristone, misoprostol and testosterone propionate can improve the success rate, accelerate the time of induced labour, shorten the bleeding time and reduce the amount of bleeding.