CAJ | 학술논문

目的：探讨新生儿败血症合并早期弥散性血管内凝血（DIC）的相关临床因素，为临床早期诊断新生儿败血症合并DIC提供参考。方法采用临床回顾研究方法对我院NICU 2012~2013年确诊为新生儿败血症的100例患儿进行研究。根据ISTH显性DIC评分系统将患儿分为凝血功能正常组、非显性DIC组（早期DIC组）及显性DIC组（晚期DIC组），对各组临床表现及相关临床因素进行统计分析。结果100例败血症患儿中合并早期DIC者44例（44%）；3组患儿硬肿的发生率差异有统计学意义（χ2=12.776，P<0.05）；窒息、出血及G-菌感染是败血症合并早期DIC的独立危险因素。结论对于临床有窒息、出血及G-菌感染的新生儿应积极监测凝血功能并采取早期干预措施，预防患儿由早期DIC进展为晚期DIC，降低新生儿败血症的病死率。
목적：탐토신생인패혈증합병조기미산성혈관내응혈（DIC）적상관림상인소，위림상조기진단신생인패혈증합병DIC제공삼고。방법채용림상회고연구방법대아원NICU 2012~2013년학진위신생인패혈증적100례환인진행연구。근거ISTH현성DIC평분계통장환인분위응혈공능정상조、비현성DIC조（조기DIC조）급현성DIC조（만기DIC조），대각조림상표현급상관림상인소진행통계분석。결과100례패혈증환인중합병조기DIC자44례（44%）；3조환인경종적발생솔차이유통계학의의（χ2=12.776，P<0.05）；질식、출혈급G-균감염시패혈증합병조기DIC적독립위험인소。결론대우림상유질식、출혈급G-균감염적신생인응적겁감측응혈공능병채취조기간예조시，예방환인유조기DIC진전위만기DIC，강저신생인패혈증적병사솔。
ObjectiveTo investigate the risk factors for early disseminated intravascular coagulation (DIC) in neonates with sepsis.MethodsA retrospective clinical study was performed on 100 neonates with a conifrmed diagnosis of sepsis between 2012 and 2013. The children were classiifed into normal coagulation group, non-overt DIC group (early DIC group), and overt DIC group (late DIC group) based on the ISTH overt DIC scoring system. The clinical manifestations and risk factors were analyzed statistically.ResultsEarly DICoccurred in 44 (44%) cases in the 100 neonates with sepsis. The incidence of sclerema showed signiifcant differences between the three groups (P<0.05). Asphyxia, bleeding, and Gram-negative bacterial infection were independent risk factors for early DIC.Conclusions Coagulation function should be actively monitored and early intervention measures should be taken for neonates with asphyxia, bleeding, and Gram-negative bacterial infection to prevent early DIC from progressing to late DIC.