CAJ | 학술논문

目的：探讨儿童青少年期起病精神分裂症患者认知功能的影响因素。方法对符合国际疾病分类第十版精神分裂症诊断标准的78名儿童青少年期起病的精神分裂症患者的临床资料进行回顾性分析。采用韦氏儿童智力测验、倒背数字、威斯康星卡片分类测验（WCST）以及P300等评估认知功能，使用阳性与阴性症状量表（PANSS）评定临床症状。结果患者的受教育年限越长，P300Fz点P3潜伏期越短；患者发病年龄越早， P300Fz点P3波潜伏期越长；患者母亲受教育年限越长，患者的IQ总分、言语IQ分、操作IQ分、WCST概念化水平百分数以及倒背分数越高；父亲受教育年限越长，患者的WCST概念化水平百分数和WCST完成分类数越高；PANSS阴性症状分量表得分高者IQ总分低、言语IQ分低、操作IQ分低、WCST概念化水平低、WCST完成分类数少以及倒背分数低，PANSS抑郁分高者倒背分数低，PANSS总分高者WCST完成分类数少以及倒背分数低；疾病稳定时间长者倒背分数高。结论阴性症状严重程度及父母受教育程度是儿童青少年期起病精神分裂症患者认知功能的主要影响因素。
목적：탐토인동청소년기기병정신분렬증환자인지공능적영향인소。방법대부합국제질병분류제십판정신분렬증진단표준적78명인동청소년기기병적정신분렬증환자적림상자료진행회고성분석。채용위씨인동지력측험、도배수자、위사강성잡편분류측험（WCST）이급P300등평고인지공능，사용양성여음성증상량표（PANSS）평정림상증상。결과환자적수교육년한월장，P300Fz점P3잠복기월단；환자발병년령월조， P300Fz점P3파잠복기월장；환자모친수교육년한월장，환자적IQ총분、언어IQ분、조작IQ분、WCST개념화수평백분수이급도배분수월고；부친수교육년한월장，환자적WCST개념화수평백분수화WCST완성분류수월고；PANSS음성증상분량표득분고자IQ총분저、언어IQ분저、조작IQ분저、WCST개념화수평저、WCST완성분류수소이급도배분수저，PANSS억욱분고자도배분수저，PANSS총분고자WCST완성분류수소이급도배분수저；질병은정시간장자도배분수고。결론음성증상엄중정도급부모수교육정도시인동청소년기기병정신분렬증환자인지공능적주요영향인소。
ObjectiveTo explore the factors influencing cognitive functions in patients with childhood and adolescence-onset schizophrenia.MethodsThe clinical data of 78 patients with childhood and adolescence-onset schizophrenia who met with the criteria of ICD-10 for schizophrenia were retrospectively reviewed. The cognitive functions were evaluated by the Chinese Wechsler Intelligence Scale for Children (C-WISC), the Wisconsin Card Sorting Test (WCST), digit span backward and P300. The clinical symptoms were evaluated by the Positive and Negative Syndrome Scale (PANSS).ResultsThe patients with a lower education level or earlier onset of age had a longer P3 latency at the P300Fz area. The patients with a higher parental education level had higher scores of full intelligence quotient (FIQ), verbal intelligence quotient (VIQ), performance intelligence quotient (PIQ), conceptual level and completed categories of WCST and backward numeric order reciting. The patients with higher PANSS negative subscale scores had lower scores of FIQ, VIQ, PIQ, completed categories and conceptual level of WCST and backward numeric order reciting. The patients with a longer stabilization time had higher backward numeric order reciting scores. ConclusionsThe severity of negative symptoms of the patients and the educational level of their parents are major factors inlfuencing cognitive functions in patients with childhood and adolescence-onset schizophrenia.