北方药学
北方藥學
북방약학
JOURNAL OF NORTH PHARMACY
2015年
4期
86-87
,共2页
消肿止痛膜气雾剂%工艺配方%正交试验
消腫止痛膜氣霧劑%工藝配方%正交試驗
소종지통막기무제%공예배방%정교시험
Swell-relieving and pain-killing aerosol%Technical formulation%Orthogonal test
目的：：优选消肿止痛膜气雾剂工艺配方。方法：以壳聚糖盐酸盐、聚乙烯吡咯烷酮PVPK30、HPMC、消肿止痛药方乙醇提取液的水平用量为考察因素，以成膜性能、成膜时间及喷射效果为指标，采用L9（34）正交试验优选消肿止痛膜气雾剂工艺配方。结果：消肿止痛膜气雾剂的最佳工艺配方为壳聚糖盐酸盐含量3%，HPMC含量0.3%，PVPK30含量3%和药方乙醇提取液30%。结论：该工艺配方合理、可行，适用于消肿止痛膜气雾剂的制备。
目的：：優選消腫止痛膜氣霧劑工藝配方。方法：以殼聚糖鹽痠鹽、聚乙烯吡咯烷酮PVPK30、HPMC、消腫止痛藥方乙醇提取液的水平用量為攷察因素，以成膜性能、成膜時間及噴射效果為指標，採用L9（34）正交試驗優選消腫止痛膜氣霧劑工藝配方。結果：消腫止痛膜氣霧劑的最佳工藝配方為殼聚糖鹽痠鹽含量3%，HPMC含量0.3%，PVPK30含量3%和藥方乙醇提取液30%。結論：該工藝配方閤理、可行，適用于消腫止痛膜氣霧劑的製備。
목적：：우선소종지통막기무제공예배방。방법：이각취당염산염、취을희필각완동PVPK30、HPMC、소종지통약방을순제취액적수평용량위고찰인소，이성막성능、성막시간급분사효과위지표，채용L9（34）정교시험우선소종지통막기무제공예배방。결과：소종지통막기무제적최가공예배방위각취당염산염함량3%，HPMC함량0.3%，PVPK30함량3%화약방을순제취액30%。결론：해공예배방합리、가행，괄용우소종지통막기무제적제비。
Objective: To optimize the formulation of swell-relieving and pain-killing aerosol. Methods: Taking the usage of Chitosan hydrochloride, PVP, PVPK30, HPMC as well as the ethanol extract of the formulation as the considering factors. Using the film-forming properties, time and spray effect as the index and adopting by L9 (34) orthogonal Test to optimize the technical formation of swell-relieving and pain-killing aerosol. Result: The best technical formulation of the swell-relieving and pain-killing aerosol is: Chitosan hydrochloride 3%, HPMC 0.3%, PVPK30 3% and 30% ethanol extract. Conclusion: The formulation is reasonable and practicable, applicable to the preparation of the swell-relieving and pain-killing aerosol.
