CAJ | 학술논문

目的：研究口腔溃疡豚鼠血清中谷胱甘肽过氧化物酶（GSH-PX）的活性。方法：用90%苯酚溶液灼烧豚鼠左侧面颊，造成口腔溃疡模型，观察豚鼠口腔溃疡模型的溃疡面积、溃疡程度及溃疡组织病理变化，测定血清中GSH-PX活性。结果：用苯酚溶液造豚鼠口腔溃疡模型成功，d1～d5，模型组与空白组相比，口腔溃疡程度显著，血清中GSH-PX活性显著降低（P<0.01）。口腔溃疡豚鼠随着时间的变化溃疡面积逐渐缩小，血清中GSH-PX活性逐渐增强。结论：血清中GSH-PX对口腔溃疡的自愈有促进作用。
목적：연구구강궤양돈서혈청중곡광감태과양화물매（GSH-PX）적활성。방법：용90%분분용액작소돈서좌측면협，조성구강궤양모형，관찰돈서구강궤양모형적궤양면적、궤양정도급궤양조직병리변화，측정혈청중GSH-PX활성。결과：용분분용액조돈서구강궤양모형성공，d1～d5，모형조여공백조상비，구강궤양정도현저，혈청중GSH-PX활성현저강저（P<0.01）。구강궤양돈서수착시간적변화궤양면적축점축소，혈청중GSH-PX활성축점증강。결론：혈청중GSH-PX대구강궤양적자유유촉진작용。
Objective:To investigate the activity of glutathione peroxidase (GSH-PX)in serum of the oral ulcer guinea pig. Methods:Guinea pig model with oral ulcer was induced by burning the left cheek with 90% phenol solution. The area of ulcer, the degree of ulcer and the changes of organization pathological were observed in guinea pig model of oral ulcer. The activity of GSH-PX was determined in serum. Results:The phenol-induced guinea pig has been established successfully.1~5d, compared with blank control group, the degree of ulcer in the model group was obvious, the activity of GSH-PX was decreased significantly(P<0.01).Along with the changes of time,the area of ulcer was decreased gradually, the activity of GSH-PX in serum was increased gradually. Conclusion:The GSH-PX in serum has a promoting role in oral ulcer healing.