功能与分子医学影像学杂志（电子版）
功能與分子醫學影像學雜誌（電子版）
공능여분자의학영상학잡지（전자판）
Functional and Molecular Medical Imaging(Electronic Edition)
2015年
1期
569-574
,共6页
李盟%江桂华%田军章%文学%张瑞彬%马晓芬%黎程%黄瑞旺
李盟%江桂華%田軍章%文學%張瑞彬%馬曉芬%黎程%黃瑞旺
리맹%강계화%전군장%문학%장서빈%마효분%려정%황서왕
成瘾%皮层厚度%吸毒年限%基于顶点%基于感兴趣区
成癮%皮層厚度%吸毒年限%基于頂點%基于感興趣區
성은%피층후도%흡독년한%기우정점%기우감흥취구
addiction%cortical thickness%duration of heroin use%vertex-wise%ROI-wise
目的：探讨海洛因成瘾对大脑皮层厚度的影响及海洛因使用年限与皮层厚度的关系。方法对18例海洛因成瘾者（HDI组）及15例健康志愿者（HC组）进行Philips?1.5?T?MR扫描获取高分辨T13D全脑结构图；利用FreeSurfer软件对图像进行分析，检测HDI组皮层厚度的异常改变。结果①基于顶点的分析结果显示，HDI组皮层厚度变薄的区域主要位于双侧额上皮层、左侧额中皮层尾部、右侧脑岛和右侧颞上皮层。皮层增厚的区域主要位于双侧舌回、左侧顶上皮层、左侧颞极、右侧枕叶外侧皮层、右侧顶下皮层和右侧楔叶；②基于感兴趣区的分析，HDI组较HC组患者左侧额上沟、左侧楔前叶、左侧距状沟、左侧侧副沟、右侧枕颞内侧和舌回皮层变薄；③HD组中右侧额上皮层和右侧脑岛的皮层厚度与海洛因使用年限呈负相关。结论海洛因成瘾者存在大脑皮层厚度改变，且吸毒年限可能是导致脑结构改变的重要影响因素。
目的：探討海洛因成癮對大腦皮層厚度的影響及海洛因使用年限與皮層厚度的關繫。方法對18例海洛因成癮者（HDI組）及15例健康誌願者（HC組）進行Philips?1.5?T?MR掃描穫取高分辨T13D全腦結構圖；利用FreeSurfer軟件對圖像進行分析，檢測HDI組皮層厚度的異常改變。結果①基于頂點的分析結果顯示，HDI組皮層厚度變薄的區域主要位于雙側額上皮層、左側額中皮層尾部、右側腦島和右側顳上皮層。皮層增厚的區域主要位于雙側舌迴、左側頂上皮層、左側顳極、右側枕葉外側皮層、右側頂下皮層和右側楔葉；②基于感興趣區的分析，HDI組較HC組患者左側額上溝、左側楔前葉、左側距狀溝、左側側副溝、右側枕顳內側和舌迴皮層變薄；③HD組中右側額上皮層和右側腦島的皮層厚度與海洛因使用年限呈負相關。結論海洛因成癮者存在大腦皮層厚度改變，且吸毒年限可能是導緻腦結構改變的重要影響因素。
목적：탐토해락인성은대대뇌피층후도적영향급해락인사용년한여피층후도적관계。방법대18례해락인성은자（HDI조）급15례건강지원자（HC조）진행Philips?1.5?T?MR소묘획취고분변T13D전뇌결구도；이용FreeSurfer연건대도상진행분석，검측HDI조피층후도적이상개변。결과①기우정점적분석결과현시，HDI조피층후도변박적구역주요위우쌍측액상피층、좌측액중피층미부、우측뇌도화우측섭상피층。피층증후적구역주요위우쌍측설회、좌측정상피층、좌측섭겁、우측침협외측피층、우측정하피층화우측설협；②기우감흥취구적분석，HDI조교HC조환자좌측액상구、좌측설전협、좌측거상구、좌측측부구、우측침섭내측화설회피층변박；③HD조중우측액상피층화우측뇌도적피층후도여해락인사용년한정부상관。결론해락인성은자존재대뇌피층후도개변，차흡독년한가능시도치뇌결구개변적중요영향인소。
ObjectiveTo study the effects of heroin exposure on cortical thickness and the relationship between?cortical?thickness?and?the?duration?of?heroin?use.?Methods In?this?study,?we?acquired?3D?high-resolution?T1?weighted?brain?structural?magnetic?resonance?imaging(MRI)data?from?18?heroin-dependent?individuals (HDIs)and?15?healthy?controls(HCs)using?a?1.5?T?MR?scanner(Phillips).?Using?FreeSurfer,?we?detected?abnormalities?in?cortical?thickness?in?the?HDIs.??Results①Based on a vertex-wise analysis, the HDIs showed significantly?decreased?cortical?thickness?in?the?bilateral?superior?frontal,?left?caudal?middle?frontal,?right?superior?temporal,?and?right?insular?regions?compared?to?the?HCs;?and?significantly?increased?cortical?thickness?in?the?left?superior?parietal,?bilateral?lingual,?left?temporal?pole,?right?inferior?parietal,?right?lateral?occipital,?and?right?cuneus?regions.?②A?subsequent?ROI-wise?analysis?showed?that,?HDIs?had?a?decreased?cortical?thickness?in?the?left?superior?frontal?sulcus,?left?precuneus?gyrus,?left?calcarine?sulcus,?left?anterior?transverse?collateral?sulcus,?and?the?right?medial?occipital-temporal?and?lingual?sulcus.?These?regions?partially?overlapped?with?the?areas?identified?using the vertex-wise analysis.③In?addition,?we?found?that?the?thickness?in?the?right?superior?frontal?and?right?insular?regions?was?negatively?correlated?with?the?duration?of?heroin?use.?Conclusion These?results?provide?compelling?evidence?for?cortical?abnormality?in?HDIs?and?also?suggest?that?the?duration?of?heroin?use?may?be?a?critical?factor?associated?with?the?brain?alteration.
