CAJ | 학술논문

海洛因成瘾者全脑功能网络拓扑结构异常的静息态功能磁共振成像研究
해락인성은자전뇌공능망락탁복결구이상적정식태공능자공진성상연구
An investigation on the disrupted topological organization in the whole-brain functional networks of heroin-dependent individuals using resting-state fMRI

万方数据

功能与分子医学影像学杂志（电子版） 공능여분자의학영상학잡지（전자판）
Functional and Molecular Medical Imaging(Electronic Edition)
2015年 1期 562-568 ,共7页

江桂华%黎超%田军章%黎程%文学%邱迎伟%张瑞彬%王俊静%李盟%马晓芬%黄瑞旺

강계화%려초%전군장%려정%문학%구영위%장서빈%왕준정%리맹%마효분%황서왕

静息态功能磁共振%全脑功能网络%海洛因%拓扑结构靜息態功能磁共振%全腦功能網絡%海洛因%拓撲結構
정식태공능자공진%전뇌공능망락%해락인%탁복결구
resting-state fMRI%functional networks%heroin%topological organization

目的：探讨海洛因成瘾者全脑功能网络的拓扑结构是否异常。方法17名海洛因成瘾者（HDIs）及15名年龄、性别与之匹配的健康对照者（NCs）参加本研究。采用1.5?T磁共振扫描仪进行静息态fMRI数据采集，使用图论法构建HDIs及NCs的脑功能网络，采用两独立样本t检验的统计学方法比较两者功能网络拓扑属性的组间差异。结果与NCs相比，HDIs具有更小的归一化聚类系数（P?=?0.049）及更低的小世界性（P?=?0.035）。HDIs认知控制网络区域的主要节点向心性显著下降，包括两侧中央扣带回、左额中回及右楔前叶，而左侧海马的主要节点向心性显著增加。左海马的节点向心性与海洛因成瘾的持续时间呈正相关。结论 HDIs的全脑功能网络遭到破坏，这有助于阐释海洛因成瘾的机制。
목적：탐토해락인성은자전뇌공능망락적탁복결구시부이상。방법17명해락인성은자（HDIs）급15명년령、성별여지필배적건강대조자（NCs）삼가본연구。채용1.5?T자공진소묘의진행정식태fMRI수거채집，사용도론법구건HDIs급NCs적뇌공능망락，채용량독립양본t검험적통계학방법비교량자공능망락탁복속성적조간차이。결과여NCs상비，HDIs구유경소적귀일화취류계수（P?=?0.049）급경저적소세계성（P?=?0.035）。HDIs인지공제망락구역적주요절점향심성현저하강，포괄량측중앙구대회、좌액중회급우설전협，이좌측해마적주요절점향심성현저증가。좌해마적절점향심성여해락인성은적지속시간정정상관。결론 HDIs적전뇌공능망락조도파배，저유조우천석해락인성은적궤제。
Objective To?investigate?whether?heroin?addiction?changes?the?topological?organization?of?whole-brain?functional?networks.?Methods Seventeen?heroin-dependent?individuals(HDIs)and?15?age,?gender?matched?normal?controls(NCs)were?enrolled,?and?the?resting-state?functional?magnetic?resonance?images (RS-fMRI)were?acquired?from?these?subjects?using?a?1.5?T?MR?scanner.?We?constructed?the?brain?functional?networks?of?HDIs?and?NCs,?and?compared?the?group?differences?in?network?topological?properties?using?graph?theory?method.?Results We?found?that?the?HDIs?showed?decreases?in?the?normalized?clustering?coefficient?and?in?small-worldness compared to the NCs. Furthermore, the HDIs exhibited significantly decreased nodal centralities primarily?in?regions?of?cognitive?control?network,?including?the?bilateral?middle?cingulate?gyrus,?left?middle?frontal?gyrus,?and?right?precuneus,?but?significantly?increased?nodal?centralities?primarily?in?the?left?hippocampus.?Moreover,?nodal?centralities?in?the?left?hippocampus?were?positively?correlated?with?the?duration?of?heroin?addiction.?Conclusion Our?results?indicated?that?disruptions?occur?in?the?whole-brain?functional?networks?of?HDIs,?findings?which?may?be?helpful?in?further?understanding?the?mechanisms?underlying?heroin?addiction.