CAJ | 학술논문

目的：观察内镜介入联合质子泵抑制剂三联疗法在消化性溃疡伴上消化道出血患者治疗中的应用效果。方法随机抽取2012年5月至2014年5月于我院接受治疗的90例消化性溃疡伴上消化道出血患者作为研究对象，按照单双号将其分为两组各45例。对照组仅给予常规质子泵抑制剂三联疗法治疗，观察组在对照组的基础上给予内镜介入疗法，对比两组患者的治疗效果，观察不良反应，比较其止血情况。结果观察组总有效率为97.8%，优于对照组的68.9%，差异有统计学意义(P<0.05)；观察组12 h止血率为75.6%，1 d后止血率为86.7%，2 d后止血率为97.8%，均明显高于对照组12 h止血率51.1%、1 d后止血率55.6%和2 d后止血率66.7%，差异具有统计学意义(P<0.05)。结论在消化性溃疡伴上消化道出血患者的临床治疗中，采用内镜介入联合质子泵抑制剂三联疗法，疗效显著，止血率高，值得推广。
목적：관찰내경개입연합질자빙억제제삼련요법재소화성궤양반상소화도출혈환자치료중적응용효과。방법수궤추취2012년5월지2014년5월우아원접수치료적90례소화성궤양반상소화도출혈환자작위연구대상，안조단쌍호장기분위량조각45례。대조조부급여상규질자빙억제제삼련요법치료，관찰조재대조조적기출상급여내경개입요법，대비량조환자적치료효과，관찰불량반응，비교기지혈정황。결과관찰조총유효솔위97.8%，우우대조조적68.9%，차이유통계학의의(P<0.05)；관찰조12 h지혈솔위75.6%，1 d후지혈솔위86.7%，2 d후지혈솔위97.8%，균명현고우대조조12 h지혈솔51.1%、1 d후지혈솔55.6%화2 d후지혈솔66.7%，차이구유통계학의의(P<0.05)。결론재소화성궤양반상소화도출혈환자적림상치료중，채용내경개입연합질자빙억제제삼련요법，료효현저，지혈솔고，치득추엄。
Objective To observe the application effect of endoscopic intervention and proton pump inhibitor (PPI) triple therapy on peptic ulcer complicating hemorrhage of upper digestive tract. Methods 90 cases of patients with peptic ulcer complicating hemorrhage of upper digestive tract treated in our hospital from May 2012 to May 2014 were selected and divided into two groups according to the odd and even number method, with 45 cases in each group. The control group only received conventional PPI triple therapy, while the observation group received endoscopic interventional therapy based on the control group. The treatment effect and hemostasis condition were compared and adverse reactions were observed. Results The total effective rate of observation group was 97.8%, better than 68.9%of control group, with statistical difference (P<0.05);the hemostasis rate after 12 h of observation group was 75.6%, the hemostasis rate after 1 d was 86.7%, the hemostasis rate after 2 d was 97.8%, higher than 51.1%, 55.6% and 66.7% of control group, with statistical difference (P <0.05). Conclusions In the treatment of patients with peptic ulcer complicating upper gastrointestinal hemorrhage, endoscopic interventional therapy combined with PPI triple therapy has significant effect and high hemostatic rate, which is worthy of promotion.