功能与分子医学影像学杂志(电子版)
功能與分子醫學影像學雜誌(電子版)
공능여분자의학영상학잡지(전자판)
Functional and Molecular Medical Imaging(Electronic Edition)
2015年
1期
579-582
,共4页
郑向东%李天然%吴贵成%郑志铖%陈凯%杨志杰%杨平生
鄭嚮東%李天然%吳貴成%鄭誌鋮%陳凱%楊誌傑%楊平生
정향동%리천연%오귀성%정지성%진개%양지걸%양평생
食管%鳞状细胞癌%同步放化疗%磁共振成像%弥散加权成像
食管%鱗狀細胞癌%同步放化療%磁共振成像%瀰散加權成像
식관%린상세포암%동보방화료%자공진성상%미산가권성상
esophagus%squamous cell carcinoma%concurrent radio chemotherapy%magnetic resonance imaging%diffusion weighted imaging
目的:利用3.0?T?MR弥散加权成像评价食管鳞状细胞癌放化疗的疗效。方法对18例食管鳞状细胞癌患者采用放疗行同步化疗,并于放化疗前及放化疗第1、3、5、10周行常规MRI平扫及DWI检查,测量并观察食管癌灶ADC值的变化。疗效根据RECIST标准评价。结果18例食管鳞状细胞癌患者,除4例失访外,14例中完全缓解2例(14.3﹪),部分缓解9例(64.3﹪),病变稳定3例(21.4﹪),病变进展0例(0﹪)。除2例完全缓解患者因病灶消失无法测量ADC值外,12例治疗前,在b值分别取600、800和1000?s/mm2时,食管癌灶ADC值分别是(1.62?±?0.23)×?10-3?mm2/s、(1.42?±?0.25)×?10-3?mm2/s、(1.21?±?0.27)×?10-3?mm2/s,同步放化疗后第10周ADC值分别是(2.77?±?0.46)×?10-3?mm2/s、(2.61?±?0.48)×?10-3?mm2/s、(2.37?±?0.49)×?10-3?mm2/s,ADC值较治疗前明显升高,差异均有统计学意义(P?=?0.000)。结论3.0?T?MR弥散加权成像对食管鳞状细胞癌放化疗的疗效评价具有一定价值。
目的:利用3.0?T?MR瀰散加權成像評價食管鱗狀細胞癌放化療的療效。方法對18例食管鱗狀細胞癌患者採用放療行同步化療,併于放化療前及放化療第1、3、5、10週行常規MRI平掃及DWI檢查,測量併觀察食管癌竈ADC值的變化。療效根據RECIST標準評價。結果18例食管鱗狀細胞癌患者,除4例失訪外,14例中完全緩解2例(14.3﹪),部分緩解9例(64.3﹪),病變穩定3例(21.4﹪),病變進展0例(0﹪)。除2例完全緩解患者因病竈消失無法測量ADC值外,12例治療前,在b值分彆取600、800和1000?s/mm2時,食管癌竈ADC值分彆是(1.62?±?0.23)×?10-3?mm2/s、(1.42?±?0.25)×?10-3?mm2/s、(1.21?±?0.27)×?10-3?mm2/s,同步放化療後第10週ADC值分彆是(2.77?±?0.46)×?10-3?mm2/s、(2.61?±?0.48)×?10-3?mm2/s、(2.37?±?0.49)×?10-3?mm2/s,ADC值較治療前明顯升高,差異均有統計學意義(P?=?0.000)。結論3.0?T?MR瀰散加權成像對食管鱗狀細胞癌放化療的療效評價具有一定價值。
목적:이용3.0?T?MR미산가권성상평개식관린상세포암방화료적료효。방법대18례식관린상세포암환자채용방료행동보화료,병우방화료전급방화료제1、3、5、10주행상규MRI평소급DWI검사,측량병관찰식관암조ADC치적변화。료효근거RECIST표준평개。결과18례식관린상세포암환자,제4례실방외,14례중완전완해2례(14.3﹪),부분완해9례(64.3﹪),병변은정3례(21.4﹪),병변진전0례(0﹪)。제2례완전완해환자인병조소실무법측량ADC치외,12례치료전,재b치분별취600、800화1000?s/mm2시,식관암조ADC치분별시(1.62?±?0.23)×?10-3?mm2/s、(1.42?±?0.25)×?10-3?mm2/s、(1.21?±?0.27)×?10-3?mm2/s,동보방화료후제10주ADC치분별시(2.77?±?0.46)×?10-3?mm2/s、(2.61?±?0.48)×?10-3?mm2/s、(2.37?±?0.49)×?10-3?mm2/s,ADC치교치료전명현승고,차이균유통계학의의(P?=?0.000)。결론3.0?T?MR미산가권성상대식관린상세포암방화료적료효평개구유일정개치。
Objective To?investigate?the?feasibility?of?using?3.0?T?diffusion-weighted?MRI?for?the?evaluation?of?radio-chemotherapy?effect?on?esophageal?squamous?cell?carcinoma. Methods 18?patients?with?esophageal?squamous?cell?carcinoma?were?recruited?for?the?study.?Concurrent?radio?chemotherapy?was?carried?out?on?these?patients.?Routine?MRI?scan?and?DWI?were?performed?on?these?patients?before?treatment?as?well?as?1、3、5、and?10?weeks?after?the?treatment.?To?measure?and?observe?the?changes?of?ADC?values?in?esophageal?carcinoma.?The?effect?of?the?therapy?was?evaluated?according?to?the?RECIST?standard.?Results Among?18?patients,?there?are?4?who?were?unable?to?follow?up.?In?the?rest?14?patients,?there?are?2?with?complete?response(14.3﹪),?9?with?partial?response(64.3﹪),?3?with?stable?disease(21.4﹪),?and?0?with?lesions?in?progress(0﹪). Except that 2?patients?with?complete?response?ADC?measurement?was?no?longer?applicable,?in?12?patients?when?b?=?600、800?and?1000?s/mm2,?ADC?values?were(1.62?±?0.23)×?10-3?mm2/s、(1.42?±?0.25)×?10-3?mm2/s、(1.21?±?0.27)×10-3?mm2/s?respectively?before?treatment,?and(2.77?±?0.46)×?10-3?mm2/s(、2.61?±?0.48)×?10-3?mm2/s?and?(2.37?±?0.49)×?10-3?mm2/s?after?tenth?week?of?the?therapy.?The?difference?was?statistically?significant(P?=?0.000).?Conclusion 3.0?T?MR?diffusion-weighted?imaging?in?esophageal?cancer?could?help?evaluate?the?curative?effects?of?concurrent?radio?chemotherapy.