CAJ | 학술논문

随着抗癫(痫)药物的发展,癫痫控制虽已取得很大进步,但有约30％的患儿经过药物合理治疗仍不能控制癫痫发作,为了控制癫痫发作及改善其神经发育预后,可采取非药物治疗,如外科手术、迷走神经刺激术及生酮饮食(KD)控制.尽管KD抗癫痫疗效十分肯定,但其作用机制仍不明确,目前主要从抗癫痫机制及神经保护机制2个方面研究.相关研究显示KD可用于治疗多种儿童难治性癫痫;而新近研究表明KD在儿童孤独症治疗中有应用前景.KD疗效虽然肯定,但其作用机制、配方、临床应用等均值得进一步研究.
수착항전(간)약물적발전,전간공제수이취득흔대진보,단유약30％적환인경과약물합리치료잉불능공제전간발작,위료공제전간발작급개선기신경발육예후,가채취비약물치료,여외과수술、미주신경자격술급생동음식(KD)공제.진관KD항전간료효십분긍정,단기작용궤제잉불명학,목전주요종항전간궤제급신경보호궤제2개방면연구.상관연구현시KD가용우치료다충인동난치성전간;이신근연구표명KD재인동고독증치료중유응용전경.KD료효수연긍정,단기작용궤제、배방、림상응용등균치득진일보연구.
There has been great progress in seizure control with the development of antiepileptic drugs,but 30％ of epileptic children are refractory to antiepileptic drugs.In order to control intractable epilepsy and improve neurodevelopment prognosis,the non-drug therapy such as surgery,vagus nerve stimulation and ketogenic diet (KD) can be taken.Despite its indisputable effectiveness,the functioning of the KD has not been explained.Now the antiepileptic mechanism and neuroprotective mechanisms are studied mainly.It is reported that KD is effective in variety of refractory epilepsy,and recent studies have shown that KD promising in the treatment of children with autism.Although KD is effective,it is worth further study that including its mechanism,recipe,clinical application,and so on.