中华实用儿科临床杂志
中華實用兒科臨床雜誌
중화실용인과림상잡지
Journal of Applied Clinical Pediatrics
2015年
6期
476-478
,共3页
支气管肺发育不良%易感基因%婴儿,早产
支氣管肺髮育不良%易感基因%嬰兒,早產
지기관폐발육불량%역감기인%영인,조산
Bronchopulmonary dysplasia%Susceptibility gene%Infant,premature
支气管肺发育不良(bronchopulmonary dysplasia,BPD)是早产儿最常见的严重慢性呼吸道疾病.近年来随着超早产儿成活率提高,BPD发病率明显增加,约10％的机械通气新生儿可发生BPD,对社会和家庭均可造成严重影响.早产儿BPD的病因多种多样,国外近期研究表明,其易感性可能与遗传因素有关,国内初步研究亦提示BPD汉族早产儿可能存在多个易感基因.现将近年来有关早产儿BPD易感基因的研究进展作一综述.
支氣管肺髮育不良(bronchopulmonary dysplasia,BPD)是早產兒最常見的嚴重慢性呼吸道疾病.近年來隨著超早產兒成活率提高,BPD髮病率明顯增加,約10％的機械通氣新生兒可髮生BPD,對社會和傢庭均可造成嚴重影響.早產兒BPD的病因多種多樣,國外近期研究錶明,其易感性可能與遺傳因素有關,國內初步研究亦提示BPD漢族早產兒可能存在多箇易感基因.現將近年來有關早產兒BPD易感基因的研究進展作一綜述.
지기관폐발육불량(bronchopulmonary dysplasia,BPD)시조산인최상견적엄중만성호흡도질병.근년래수착초조산인성활솔제고,BPD발병솔명현증가,약10％적궤계통기신생인가발생BPD,대사회화가정균가조성엄중영향.조산인BPD적병인다충다양,국외근기연구표명,기역감성가능여유전인소유관,국내초보연구역제시BPD한족조산인가능존재다개역감기인.현장근년래유관조산인BPD역감기인적연구진전작일종술.
Bronchopulmonary dysplasia (BPD) is one of the most common serious chronic respiratory diseases in premature infants.In recent years,BPD has been significantly increasing with the improved survival rate of extremely preterm babies.About 10％ of neonates with mechanical ventilation might suffer from BPD,and this may lead to a great burden and costs to both the family and the society.A variety of risk factors has been proposed to be associated with BPD in preterm infants.However recent abroad researches indicated that genetic factors might predispose to BPD of preterm neonates,and initial results of domestic related researches inferred that several susceptibility genes might contribute to BPD development in Han preterm infants.This review focuses on recent publications related to genetic factors that may potentially contribute to BPD.
