中华实用儿科临床杂志
中華實用兒科臨床雜誌
중화실용인과림상잡지
Journal of Applied Clinical Pediatrics
2015年
6期
473-475
,共3页
临床孤立综合征%多发性硬化%转归%预测
臨床孤立綜閤徵%多髮性硬化%轉歸%預測
림상고립종합정%다발성경화%전귀%예측
Clinically isolated syndrome%Multiple sclerosis%Conversion%Prediction
临床孤立综合征(CIS)是指首次发作的中枢神经系统炎性脱髓鞘事件,病变常累及视神经、脑干或脊髓等部位,30％～ 70％的CIS可转化为多发性硬化(MS).目前认为,疾病修正治疗可延缓CIS向MS的转化,然而因其对疾病最终影响的不确定性及治疗的不良反应,临床使用比较局限且指征严格.现对CIS进展为MS的预测因素的研究进展进行综述,以期为临床治疗提供参考.
臨床孤立綜閤徵(CIS)是指首次髮作的中樞神經繫統炎性脫髓鞘事件,病變常纍及視神經、腦榦或脊髓等部位,30％～ 70％的CIS可轉化為多髮性硬化(MS).目前認為,疾病脩正治療可延緩CIS嚮MS的轉化,然而因其對疾病最終影響的不確定性及治療的不良反應,臨床使用比較跼限且指徵嚴格.現對CIS進展為MS的預測因素的研究進展進行綜述,以期為臨床治療提供參攷.
림상고립종합정(CIS)시지수차발작적중추신경계통염성탈수초사건,병변상루급시신경、뇌간혹척수등부위,30％～ 70％적CIS가전화위다발성경화(MS).목전인위,질병수정치료가연완CIS향MS적전화,연이인기대질병최종영향적불학정성급치료적불량반응,림상사용비교국한차지정엄격.현대CIS진전위MS적예측인소적연구진전진행종술,이기위림상치료제공삼고.
A clinically isolated syndrome(CIS) is a term that describes a first clinical episode in which a patient has symptoms and signs suggestive of an inflammatory demyelinating disorder of the central nervous system.And it often affects optic nerves,the brainstem,or the spinal cord,and 30％-70％ of the CIS patients may develop multiple sclerosis(MS).Disease-modifying treatments may delay the development from CIS to MS.Their use in CIS is limited because of uncertain long-term clinical prognosis,treatment benefits and adverse effects.This article reviews the advances of predictive markers of conversion to MS after a CIS,in order to provide the reference for clinical treatment.
