CAJ | 학술논문

聚乙二醇干扰素（PEG－IFN）α治疗慢性乙型肝炎（CHB）应答受宿主遗传背景、免疫状态、病毒基因型、病毒载量等多重因素的影响。概述了宿主白细胞介素（IL）28B基因多态性、基线干扰素诱导蛋白10、IL－17A、IL－10、肿瘤坏死因子α水平、病毒载量及基因型、治疗12和24周HBsAg、HBeAg血清水平变化为实现HBsAg、HBeAg消失及血清学转换、持久病毒学应答的重要预测因素。对近年来关于CHB患者PEG－IFNα治疗应答相关因素研究作一综述。
취을이순간우소（PEG－IFN）α치료만성을형간염（CHB）응답수숙주유전배경、면역상태、병독기인형、병독재량등다중인소적영향。개술료숙주백세포개소（IL）28B기인다태성、기선간우소유도단백10、IL－17A、IL－10、종류배사인자α수평、병독재량급기인형、치료12화24주HBsAg、HBeAg혈청수평변화위실현HBsAg、HBeAg소실급혈청학전환、지구병독학응답적중요예측인소。대근년래관우CHB환자PEG－IFNα치료응답상관인소연구작일종술。
The treatment responses to pegylated interferon alpha (PEG-IFNα)in patients with chronic hepatitis B (CHB)are associated with the genetic polymorphisms,immune status,hepatitis B virus genotype,and viral load of the host.This article reviews the recent studies on influential factors for the responses to PEG-IFNαin CHB patients.The important predictors of the clearance and seroconversion of HB-sAg and HBeAg and sustained virological response include interleukin-28B (IL-28B)gene polymorphism,baseline level of interferon-inducible protein-10,IL-17A,IL-10,tumor necrosis factor-α,viral load and genotype,and changes in serum HBsAg and HBeAg levels at weeks 12 and 24 of treatment.