中华神经外科杂志
中華神經外科雜誌
중화신경외과잡지
Chinese Journal of Neurosurgery
2015年
3期
228-232
,共5页
张楠%刘正言%陈宏%李士其%于佶%张恒柱
張楠%劉正言%陳宏%李士其%于佶%張恆柱
장남%류정언%진굉%리사기%우길%장항주
垂体肿瘤%节细胞瘤%病理学%神经外科手术
垂體腫瘤%節細胞瘤%病理學%神經外科手術
수체종류%절세포류%병이학%신경외과수술
Pituitary neoplasms%Gangliocytoma%Pathology%Neurosurgical procedures
目的 总结垂体节细胞瘤的临床病理特征及治疗方法.方法 回顾性分析8例经手术和病理证实的垂体节细胞瘤患者的临床、病理资料及术后随访结果.结果 5例全切除,3例次全切除.病理显示节细胞瘤与垂体腺瘤细胞合并存在是其典型特征,其中4例为垂体生长激素(GH)腺瘤伴节细胞瘤,2例为垂体多激素腺瘤伴节细胞瘤,1例为垂体无激素型腺瘤伴节细胞瘤,1例为垂体节细胞瘤.平均随访4.7年,所有患者症状均缓解;3例次全切除患者中2例行伽玛刀治疗,l例观察随访;鞍区MRI复查示肿瘤7例消失,1例残留未见增大.结论 绝大多数垂体节细胞瘤与垂体腺瘤合并存在.临床多表现为内分泌紊乱症状,以肢端肥大症常见.诊断主要依靠病理组织学、免疫组化标记,GH及生长激素释放激素(GHRH)阳性为其重要特征.经蝶窦手术切除是首选治疗方法,若有残留可行伽玛刀治疗,预后良好.
目的 總結垂體節細胞瘤的臨床病理特徵及治療方法.方法 迴顧性分析8例經手術和病理證實的垂體節細胞瘤患者的臨床、病理資料及術後隨訪結果.結果 5例全切除,3例次全切除.病理顯示節細胞瘤與垂體腺瘤細胞閤併存在是其典型特徵,其中4例為垂體生長激素(GH)腺瘤伴節細胞瘤,2例為垂體多激素腺瘤伴節細胞瘤,1例為垂體無激素型腺瘤伴節細胞瘤,1例為垂體節細胞瘤.平均隨訪4.7年,所有患者癥狀均緩解;3例次全切除患者中2例行伽瑪刀治療,l例觀察隨訪;鞍區MRI複查示腫瘤7例消失,1例殘留未見增大.結論 絕大多數垂體節細胞瘤與垂體腺瘤閤併存在.臨床多錶現為內分泌紊亂癥狀,以肢耑肥大癥常見.診斷主要依靠病理組織學、免疫組化標記,GH及生長激素釋放激素(GHRH)暘性為其重要特徵.經蝶竇手術切除是首選治療方法,若有殘留可行伽瑪刀治療,預後良好.
목적 총결수체절세포류적림상병리특정급치료방법.방법 회고성분석8례경수술화병리증실적수체절세포류환자적림상、병리자료급술후수방결과.결과 5례전절제,3례차전절제.병리현시절세포류여수체선류세포합병존재시기전형특정,기중4례위수체생장격소(GH)선류반절세포류,2례위수체다격소선류반절세포류,1례위수체무격소형선류반절세포류,1례위수체절세포류.평균수방4.7년,소유환자증상균완해;3례차전절제환자중2례행가마도치료,l례관찰수방;안구MRI복사시종류7례소실,1례잔류미견증대.결론 절대다수수체절세포류여수체선류합병존재.림상다표현위내분비문란증상,이지단비대증상견.진단주요의고병리조직학、면역조화표기,GH급생장격소석방격소(GHRH)양성위기중요특정.경접두수술절제시수선치료방법,약유잔류가행가마도치료,예후량호.
Objective To summarize the clinical pathological characteristics and treatment of pituitary gangliocytoma.Methods The clinical,pathological features and follow-up results of 8 patients with pituitary gangliocytoma were retrospectively analyzed.Results Total resection was achieved in 5 patients and subtotal in 3.This kind of lesion was pathologically characterized by the coexistence of pituitary gangliocytoma and pituitary adenoma.Four cases were diagnosed as pituitary growth hormone(GH) adenoma with gangliocytoma,2 pituitary plurihormonal adenoma with gangliocytoma,1 pituitary hormonenegative adenoma with gangliocytoma,and 1 pituitary gangliocytoma.The mean follow-up period was 4.7 years.Of the 3 patients who failed to achieve total resection,2 underwent gamma knife surgery,1 was intimately followe-up.The postoperative MRI examinations showed that the tumors disappeared in 7 cases,the remnant tumor of the patient who did not undergo gamma knife surgery remained unchanged.Conclusions The majority of pituitary ganliocytomas coexisted with pituitary adenomas.The endocrine disorders,especially acromegaly,were the most common clinical manifestations.The correct diagnosis of pituitary gangliocytoma should be based on the histopathological and immunohistochemical results.The positive result of GH and growth hormone releasing hormone (GHRH) staining was a key feature of this kind of tumor.Although transsphenoidal microsurgery was the choice of treatment,gamma knife surgery should be considered if the total resection could not be achieved.Pituitary gangliocytoma was a benign tumor with optimistic prognosis.