CAJ | 학술논문

目的探讨局灶性脑皮质发育不良(FCD)致难治性癫痫的病理分型、头颅MRI检查结果、致痫灶所在脑叶位置、致痫灶切除程度与手术预后的关系.方法回顾性分析2009年12月至2012年12月新疆医科大学第一附属医院神经外科收治的61例FCD致难治性癫痫患者的手术效果.随访时间为1～3年,同时分析病理分型、头颅MRI检查结果、致痫灶所在脑叶位置、致痫灶切除程度与手术预后的关系.结果术后Engel分级Ⅰ级42例(69％),Ⅱ级10例(16％),Ⅲ级5例(8％),Ⅳ级4例(7％).FCD致顽固性癫痫的手术预后与病理分型、头颅MRI检查结果、致痫灶是否位于单纯颞叶、致痫灶是否完全切除均有关(均P ＜0.05).结论 FCD所致难治性癫痫的总体手术效果良好.结合型FCD、头颅MRI检查阳性、致痫灶位于单纯颞叶、致痫灶全切除的患者手术预后良好.
목적 탐토국조성뇌피질발육불량(FCD)치난치성전간적병리분형、두로MRI검사결과、치간조소재뇌협위치、치간조절제정도여수술예후적관계.방법 회고성분석2009년12월지2012년12월신강의과대학제일부속의원신경외과수치적61례FCD치난치성전간환자적수술효과.수방시간위1～3년,동시분석병리분형、두로MRI검사결과、치간조소재뇌협위치、치간조절제정도여수술예후적관계.결과 술후Engel분급Ⅰ급42례(69％),Ⅱ급10례(16％),Ⅲ급5례(8％),Ⅳ급4례(7％).FCD치완고성전간적수술예후여병리분형、두로MRI검사결과、치간조시부위우단순섭협、치간조시부완전절제균유관(균P ＜0.05).결론 FCD소치난치성전간적총체수술효과량호.결합형FCD、두로MRI검사양성、치간조위우단순섭협、치간조전절제적환자수술예후량호.
Objective To analyze the surgical outcome and relevant surgical parameters including pathological subtype,brain MRI results,the location of epileptogenic zone,resection extent of epileptogenic zone in focal cortical dysplasia (FCD) with intractable epilepsy.Methods We retrospectively analyzed the surgical outcomes of 61 patients with intractable epilepsy related to FCD,accepted surgery in the First Affiliated Hospital of Xinjiang Medical University from December 2009 to December 2012,with 1-3 years of postoperative follow-up.The relation between pathological subtypes,MRI results,epileptogenic zone located at pure temporal lobe,resection extent of epileptogenic zone and surgical outcomes were statistically evaluated.Results Forty-two patients(69％) were Engel class Ⅰ,10 (16％) class Ⅱ,5 (8％) class Ⅲ,and 4 (7％) class Ⅳ.The surgical outcome was related with pathological subtype(P ＜0.05),brain MRI results(P ＜ 0.05),whether the epileptogenic zone located at pure temporal lobe (P ＜ 0.05),whether complete resection(P ＜0.05).Conclusions The surgical outcome of FCD was favorable.FCD type Ⅲ,positive brain MRI results,epileptogenic zone located at pure temporal lobe,complete resection were correlated with favorable surgical outcome.