CAJ | 학술논문

目的：精确检测低密度脂蛋白(low density lipoprotein,LDL)的亚组分并评估其中的小而密低密度脂蛋白(small dense LDL,sdLDL)与青年角膜弓(简称青年弓)的相关性。方法入选12例2014年3月至2014年10月就诊于首都医科大学附属北京安贞医院眼科及体检中心的血脂正常的青年弓患者。另外选取12例年龄、性别、吸烟史相匹配的健康对照者。采用Lipoprint LDL System精确检测LDL的亚组分,计算其中的sdLDL占LDL的百分数,即sdLDL比率( sdLDL%)。采用t检验比较青年弓组与对照组的sdLDL%,再以青年弓为因变量,通过Logistic回归分析( Backward：LR)评估其相关因素。结果与对照组相比,青年弓组sdLDL%数值偏高[(13.16±6.29)% vs (19.64±6.52)%],差异有统计学意义(P=0.020)。 Logistic回归分析显示：将年龄、LDL校正后,sdLDL%增高和青年弓明显相关(P=0.040)。 sdLDL%是青年弓发生的危险因素(OR=1.49,95%CI：1.01~2.19,P<0.05)。结论血脂正常青年弓患者的sdLDL%增高,表明其LDL亚组分异常。
목적：정학검측저밀도지단백(low density lipoprotein,LDL)적아조분병평고기중적소이밀저밀도지단백(small dense LDL,sdLDL)여청년각막궁(간칭청년궁)적상관성。방법입선12례2014년3월지2014년10월취진우수도의과대학부속북경안정의원안과급체검중심적혈지정상적청년궁환자。령외선취12례년령、성별、흡연사상필배적건강대조자。채용Lipoprint LDL System정학검측LDL적아조분,계산기중적sdLDL점LDL적백분수,즉sdLDL비솔( sdLDL%)。채용t검험비교청년궁조여대조조적sdLDL%,재이청년궁위인변량,통과Logistic회귀분석( Backward：LR)평고기상관인소。결과여대조조상비,청년궁조sdLDL%수치편고[(13.16±6.29)% vs (19.64±6.52)%],차이유통계학의의(P=0.020)。 Logistic회귀분석현시：장년령、LDL교정후,sdLDL%증고화청년궁명현상관(P=0.040)。 sdLDL%시청년궁발생적위험인소(OR=1.49,95%CI：1.01~2.19,P<0.05)。결론혈지정상청년궁환자적sdLDL%증고,표명기LDL아조분이상。
Objective To exactly analyze low density lipoprotein( LDL) subclass and examine the association between small dense LDL( sdLDL) and corneal arcus in young patients. Methods We selected 12 cases of young patients with corneal arcus and normal serum lipids. Another 12 control cases with matched age, gender, smoking were recruited from Beijing Anzhen Hospital between March 2014 and October 2014. LDL particle separation was performed by Lipoprint System: LDL subfractions were obtained and sdLDL proportion(% of sdLDL particles) was calculated. sdLDL% was compared with the Student t test between two groups. Logistic regression analysis was performed to evaluate the correlation between corneal arcus and its related factors. Results SdLDL% was increased in corneal arcus group compared with controls[(19. 64±6. 52)% vs (13. 16±6. 29)%]. The difference between the two groups was significant(P=0. 020). SdLDL% was significantly associated with corneal arcus(P=0. 040) after controlling for age and LDL. SdLDL%played a role in the development of corneal arcus(OR=1. 49, 95%CI:1. 01-2. 19, P<0. 05). Conclusion These findings suggested that young patients with corneal arcus and normal serum lipids had increased level of sdLDL proportion, indicating the abnormality of LDL subclass in such cases.