CAJ | 학술논문

目的：观察双波长强脉冲光（intense pulsed light,IPL）联合0.1%他克莫司软膏治疗玫瑰痤疮的疗效及安全性。方法：将65例I型及II型玫瑰痤疮患者随机分为联合组、IPL组及他克莫司（Tacrolimus，TLM）治疗组。联合组及IPL组采用双波长IPL治疗，每2周1次，共治疗3次，同时，联合组及TLM组采用0.1%他克莫司软膏，每日2次，连续8周。由两位盲态医生对患者的皮损评分并记录不良反应，共8周。结果：研究第8周，联合组、IPL组及TLM组治疗前后积分差值分别为7.76±2.37、7.41±2.06及5.40±2.92，差异有显著性(P<0.05)；三组总有效率分别为84.85%、82.35%及46.66%；均未见严重不良反应。结论：IPL及0.1%他克莫司软膏治疗玫瑰痤疮均安全，IPL的短期疗效优于0.1%他克莫司软膏，IPL短期联合0.1%他克莫司软膏与单独采用IPL比较未体现出明显优势。
목적：관찰쌍파장강맥충광（intense pulsed light,IPL）연합0.1%타극막사연고치료매괴좌창적료효급안전성。방법：장65례I형급II형매괴좌창환자수궤분위연합조、IPL조급타극막사（Tacrolimus，TLM）치료조。연합조급IPL조채용쌍파장IPL치료，매2주1차，공치료3차，동시，연합조급TLM조채용0.1%타극막사연고，매일2차，련속8주。유량위맹태의생대환자적피손평분병기록불량반응，공8주。결과：연구제8주，연합조、IPL조급TLM조치료전후적분차치분별위7.76±2.37、7.41±2.06급5.40±2.92，차이유현저성(P<0.05)；삼조총유효솔분별위84.85%、82.35%급46.66%；균미견엄중불량반응。결론：IPL급0.1%타극막사연고치료매괴좌창균안전，IPL적단기료효우우0.1%타극막사연고，IPL단기연합0.1%타극막사연고여단독채용IPL비교미체현출명현우세。
Objective To evaluate the efficacy and safety of combination therapy of dual wavelength Intense Pulsed Light (IPL) and topical tacrolimus 0.1% ointment on treatment of rosacea. Methods Sixty-five subjects with erythematotelangiectatic rosacea or papulopustular rosacea were divided randomly into three groups. Group combination and group IPL were treated with 3 sessions of IPL at 2 weeks intervals, group combination and group TLM received tacrolimus 0.1%ointment twice daily for 8 weeks.Scores and side effects were evaluated and recorded by physician's assessment by two blinded dermatologists for 8 weeks. Results At 8th week, the decline in severity scores of the group combination,IPL and TLM was 7.76 ± 2.37,7.41 ± 2.06 and 5.40 ± 2.92 respectively,the differences between the three groups were significant (P<0.05).Total efficiencies of the group combination, group IPL and group TLM were 84.85,82.35% and 42.11% respectively.No serious adverse event was observed in either group. Conclusion IPL and tacrolimus 0.1% ointment are both safe for treatment of rosacea,IPL improves rosacea better than tacrolimus 0.1% ointment for 8 weeks'treatment,short-term combination therapy of IPL and tacrolimus 0.1% ointment on rosacea has no clear advantage over that of IPL.