中国美容医学
中國美容醫學
중국미용의학
CHINESE JOURNAL OF AESTHETIC MEDICINE
2015年
5期
55-57
,共3页
体外培育牛黄%夫西地酸乳膏%寻常性痤疮
體外培育牛黃%伕西地痠乳膏%尋常性痤瘡
체외배육우황%부서지산유고%심상성좌창
in vitro Cultivated Calculus Bovis%fusidic acid cream%acne vulgaris
目的：观察体外培育牛黄联合夫西地酸乳膏治疗寻常性痤疮的临床疗效及安全性。方法：采用开放、随机、平行对照方法，按照中国痤疮治疗指南痤疮严重程度标准入选中度(Ⅲ级)寻常性痤疮患者70例，随机分为两组。治疗组：35例，外用夫西地酸乳膏，每日2次，同时口服体外培育牛黄0.15g，每日1次；对照组：35例，外用夫西地酸乳膏，每日2次，共用药3周。在基线、治疗1、2、3周时分别记录患者白头粉刺、黑头粉刺、炎性丘疹、脓疱数目，进行疗效评定，同时记录皮肤其他不良反应。结果：在治疗1周时，治疗组总有效率为51.43%，对照组为42.86%，两组差异无统计学意义(P>0.05)；但在治疗2周及3周时，治疗组总有效率优于对照组(P<0.05)。两组不良反应类似，均表现为局部刺激，腹泻，可耐受。治疗结束3周后，复发率治疗组明显低于对照组，差异有统计学意义。结论：体外培育牛黄联合夫西地酸乳膏治疗寻常性痤疮总有效率优于单用夫西地酸乳膏，体外培育牛黄联合夫西地酸乳膏治疗寻常性痤疮疗效显著、安全，且复发率低，值得临床推广使用。
目的：觀察體外培育牛黃聯閤伕西地痠乳膏治療尋常性痤瘡的臨床療效及安全性。方法：採用開放、隨機、平行對照方法，按照中國痤瘡治療指南痤瘡嚴重程度標準入選中度(Ⅲ級)尋常性痤瘡患者70例，隨機分為兩組。治療組：35例，外用伕西地痠乳膏，每日2次，同時口服體外培育牛黃0.15g，每日1次；對照組：35例，外用伕西地痠乳膏，每日2次，共用藥3週。在基線、治療1、2、3週時分彆記錄患者白頭粉刺、黑頭粉刺、炎性丘疹、膿皰數目，進行療效評定，同時記錄皮膚其他不良反應。結果：在治療1週時，治療組總有效率為51.43%，對照組為42.86%，兩組差異無統計學意義(P>0.05)；但在治療2週及3週時，治療組總有效率優于對照組(P<0.05)。兩組不良反應類似，均錶現為跼部刺激，腹瀉，可耐受。治療結束3週後，複髮率治療組明顯低于對照組，差異有統計學意義。結論：體外培育牛黃聯閤伕西地痠乳膏治療尋常性痤瘡總有效率優于單用伕西地痠乳膏，體外培育牛黃聯閤伕西地痠乳膏治療尋常性痤瘡療效顯著、安全，且複髮率低，值得臨床推廣使用。
목적：관찰체외배육우황연합부서지산유고치료심상성좌창적림상료효급안전성。방법：채용개방、수궤、평행대조방법，안조중국좌창치료지남좌창엄중정도표준입선중도(Ⅲ급)심상성좌창환자70례，수궤분위량조。치료조：35례，외용부서지산유고，매일2차，동시구복체외배육우황0.15g，매일1차；대조조：35례，외용부서지산유고，매일2차，공용약3주。재기선、치료1、2、3주시분별기록환자백두분자、흑두분자、염성구진、농포수목，진행료효평정，동시기록피부기타불량반응。결과：재치료1주시，치료조총유효솔위51.43%，대조조위42.86%，량조차이무통계학의의(P>0.05)；단재치료2주급3주시，치료조총유효솔우우대조조(P<0.05)。량조불량반응유사，균표현위국부자격，복사，가내수。치료결속3주후，복발솔치료조명현저우대조조，차이유통계학의의。결론：체외배육우황연합부서지산유고치료심상성좌창총유효솔우우단용부서지산유고，체외배육우황연합부서지산유고치료심상성좌창료효현저、안전，차복발솔저，치득림상추엄사용。
Objective To investigate the clinical efficacy and safety of in vitro Cultivated Calculus Bovis combined with fusidic acid cream in the treatment of mild to moderate acne vulgaris. Methods A open, randomized, parallel, controlled clinical study was conducted.70 cases with acne vulgaris (Grade III) were enrolled in this study and randomly divided into 2 groups.35 cases in treatment group were treated by 2%fusidic acid cream combined with in vitro Cultivated Calculus Bovis; 35cases in control group were treated with 2%fusidic acid cream.All the patients received therapy for 3 weeks continuously and the efficacy had been evaluated at the baseline, 1 and 2 weeks of treatment for the count of comedones (both open and closed),inflammatory papules and pustules and adverse effects. Results The total response rate was 51.43%in the treatment group and 42.86%in the control group on week1 (P>0.05),however, The total response rate of the treatment group were better than of the control group on 2 and 3 week(P<0.05).Adverse reactions were similar in both groups and manifested as tolerable local irritation, diarrhea. Conclusion In vitro Cultivated Calculus Bovis combined with fusidic acid cream was effective and safe in the treatment of mild to moderate (Grade III) acne vulgaris.
