CAJ | 학술논문

影响HBV感染／清除及抗病毒疗效的因素极为复杂，如宿主、病毒、环境等。近年来研究证明白细胞介素（IL）28B基因多态性与HCV清除及抗病毒治疗高度相关，国内外许多学者开始关注IL－28B 基因变异在慢性乙型肝炎（CHB）中的作用，其中rs12979860、rs12980275、rs80999173个位点成为研究热点。总结了IL－28B基因多态性在HBV感染／清除及CHB患者干扰素治疗中的作用，虽然尚无定论，但目前认为IL－28B基因多态性可能在CHB领域中具有重要的潜在临床价值。
영향HBV감염／청제급항병독료효적인소겁위복잡，여숙주、병독、배경등。근년래연구증명백세포개소（IL）28B기인다태성여HCV청제급항병독치료고도상관，국내외허다학자개시관주IL－28B 기인변이재만성을형간염（CHB）중적작용，기중rs12979860、rs12980275、rs80999173개위점성위연구열점。총결료IL－28B기인다태성재HBV감염／청제급CHB환자간우소치료중적작용，수연상무정론，단목전인위IL－28B기인다태성가능재CHB영역중구유중요적잠재림상개치。
The infection/clearance and antiviral therapy of hepatitis B virus (HBV)are affected by various factors,such as the host,virus, and environment.Recent studies have proven that interleukin 28B (IL-28B)polymorphisms are highly associated with the clearance and antiviral therapy of hepatitis C virus.Since then,great attention has been paid to the role of IL-28B genetic variations in chronic hepatitis B (CHB),with a research focus on the loci rs12979860,rs12980275,and rs8099917.This paper reviews the role of IL-28B polymor-phisms in the infection/clearance of HBV and interferon therapy of CHB.Despite the conflicting findings,IL-28B polymorphisms are con-sidered to have a potential clinical value in the field of CHB.