CAJ | 학술논문

HBV感染过程受多种因素的综合调控。白细胞介素（IL）10是免疫调节的必需因子，IL－10基因启动子多态性影响 IL－10 mRNA的转录，从而影响血清IL－10水平。IL－10与HBV感染转归、预后有关联。简述了IL－10基因多态性与血清IL－10的关系和IL－10基因多态性与HBV感染转归的联系，对IL－10作为炎症反应抑制因子，在机体免疫功能、HBV感染转归、HBV发展及其相关并发症的发生发展方面的作用进行了综述。认为IL－10基因多态性及血清IL－10与HBV感染后炎症反应关系密切，影响机体清除HBV，并与HBV感染肝损害程度、HBV 感染肝硬化、HBV 相关肝细胞癌有关。检测IL－10基因及血清水平对预测HBV感染转归有一定的指导意义。
HBV감염과정수다충인소적종합조공。백세포개소（IL）10시면역조절적필수인자，IL－10기인계동자다태성영향 IL－10 mRNA적전록，종이영향혈청IL－10수평。IL－10여HBV감염전귀、예후유관련。간술료IL－10기인다태성여혈청IL－10적관계화IL－10기인다태성여HBV감염전귀적련계，대IL－10작위염증반응억제인자，재궤체면역공능、HBV감염전귀、HBV발전급기상관병발증적발생발전방면적작용진행료종술。인위IL－10기인다태성급혈청IL－10여HBV감염후염증반응관계밀절，영향궤체청제HBV，병여HBV감염간손해정도、HBV 감염간경화、HBV 상관간세포암유관。검측IL－10기인급혈청수평대예측HBV감염전귀유일정적지도의의。
Multiple etiological factors are integrally involved in the development of hepatitis B virus (HBV)infection.Interleukin-10 (IL-10)is an essential cytokine of immune regulation,and IL-10 gene promoter polymorphism affects its mRNA transcription and serum level. IL-10 is related to the prognosis of HBV infection.This review briefly discusses the association of IL-10 gene polymorphism and its serum level with the prognosis of HBV infection,and summarizes the role of IL-10,as an anti-inflammatory cytokine,in host immune function, the prognosis and progression of HBV infection,and HBV-related complications.IL-10 gene polymorphism and its serum level are closely associated with inflammatory response after HBV infection,influence HBV clearance,and are related to the severity of HBV-related liver injury,liver cirrhosis,and hepatocellular carcinoma.The determination of IL-10 gene and serum levels may provide a predictive marker for the prognosis of HBV infection.