CAJ | 학술논문

核苷和核苷酸类药物长期单药抗HBV治疗过程中易导致病毒发生耐药突变，可能与慢性乙型肝炎的重症化和原发性肝癌的发生相关，是目前研究热点之一。深入理解耐药变异株在长期抗病毒治疗中的演变特征，在基因型耐药发生至病毒学突破发生的时间间隔内，选择适用于临床耐药的监测方法，动态监测耐药株在准种池中的比例变化，及时更改治疗方案，对慢性乙型肝炎的优化治疗有重要的指导意义，同时也有助于研发高效的抗病毒药物。
핵감화핵감산류약물장기단약항HBV치료과정중역도치병독발생내약돌변，가능여만성을형간염적중증화화원발성간암적발생상관，시목전연구열점지일。심입리해내약변이주재장기항병독치료중적연변특정，재기인형내약발생지병독학돌파발생적시간간격내，선택괄용우림상내약적감측방법，동태감측내약주재준충지중적비례변화，급시경개치료방안，대만성을형간염적우화치료유중요적지도의의，동시야유조우연발고효적항병독약물。
Long-term antiviral therapy with nucleos(t)ide analogues against hepatitis B virus may lead to the occurrence of drug-resistant viral mutations.As a challenging topic in antiviral research,the problem of drug-resistant mutations may be associated with the aggregation of chronic hepatitis B and the development of primary hepatic carcinoma.In-depth understanding of the evolution characteristics of drug-resistant mutants during long-term antiviral therapy will allow a selection of appropriate clinical drug resistance monitoring approach.Within the time interval between the occurrence of genotypic resistance and virological breakthrough,dynamic monitoring of variations in the propor-tion of drug-resistant variants in the quasispecies pool and timely change of the therapeutic regimen will help to optimize the treatment of chronic hepatitis B and develop effective antiviral drugs.