CAJ | 학술논문

目的：了解再生障碍性贫血、急性淋巴细胞白血病及髓系白血病患者EB病毒（EBV ）和人巨细胞病毒（HCM V ）核酸检测阳性率与其年龄的关系。方法收集中国人民解放军海军总医院2012年1月至2013年12月骨髓穿刺后临床确诊为再生障碍性贫血、急性淋巴细胞白血病及髓系白血病患者为研究对象，采用达安基因核酸检测试剂盒对 EBV和 HCM V核酸进行检测，分析EBV和 HCM V感染阳性率与患者年龄的关系。结果 EBV和 HCM V在3种血液病中核酸检测阳性率不同，HCM V核酸检测阳性检出率（15．8％）低于EBV （43．7％）。再生障碍性贫血和髓系白血病患者中，不同年龄患者EBV核酸检测阳性率比较差异有统计学意义（P＜0．01）。结论对于儿童再生障碍性贫血病和髓系白血病患者应更加重视 EBV和HCMV核酸的监测。
목적：료해재생장애성빈혈、급성림파세포백혈병급수계백혈병환자EB병독（EBV ）화인거세포병독（HCM V ）핵산검측양성솔여기년령적관계。방법수집중국인민해방군해군총의원2012년1월지2013년12월골수천자후림상학진위재생장애성빈혈、급성림파세포백혈병급수계백혈병환자위연구대상，채용체안기인핵산검측시제합대 EBV화 HCM V핵산진행검측，분석EBV화 HCM V감염양성솔여환자년령적관계。결과 EBV화 HCM V재3충혈액병중핵산검측양성솔불동，HCM V핵산검측양성검출솔（15．8％）저우EBV （43．7％）。재생장애성빈혈화수계백혈병환자중，불동년령환자EBV핵산검측양성솔비교차이유통계학의의（P＜0．01）。결론대우인동재생장애성빈혈병화수계백혈병환자응경가중시 EBV화HCMV핵산적감측。
Objective To understand the relationship between the positive rate of Epstain‐Barr virus (EBV) and human cyto‐megalovirus (HCMV) nucleic acid detection with the age in the patients with aplastic anemia ,acute lymphoblastic leukemia and my‐eloid leukemia .Methods The patients clinically diagnosed as aplastic anemia ,acute lymphoblastic leukemia ,and myeloid leukemia after bone marrow puncture in the Navy General Hospital from January 2012 to December 2013were collected as the research sub‐jects .the nucleic acid test kit from DAAN Gene Company was adopted for conducting the EBV and HCMV nucleic acid testing and analyzing the relationship between the positive rate of the EBV and HCMV infection with the patient′s age .Results There were different testing positive rate among 3 kinds of hematonosis .As a whole ,the positive rate of HCMV was lower than that of EBV (15 .8% vs .43 .7% ) .The EBV nucleic acid detection positive rate had statistically significant difference among different ages of pa‐tients with aplastic anemia and myeloid leukemia .(P< 0 .01) .Conclusion For children patients with aplastic anemia disease and myeloid leukemia ,more attention should be paid to monitoring of EBV and HCM V nucleic acid .