CAJ | 학술논문

目的：探讨血清同型半胱氨酸（Hcy）、叶酸（FA）及维生素B12（VitB12）水平与脑梗死的关系。方法采用循环酶法和化学发光免疫法分别检测60例脑梗死患者血清 Hcy、FA及VitB12水平，并与同期40例健康体检者进行比较。结果脑梗死组血清Hcy水平（23．16±8．17μmol／L）明显高于对照组（8．09±2．45μmol／L ，P＜0．01），血清FA水平（6．12±2．19 ng／mL）和VitB12水平（323．92±133．79μmol／L）明显低于对照组（10．57±5．70 ng／mL ，530．85±168．56μmol／L ，P＜0．01）。脑梗死组血清Hcy水平与FA及VitB12水平均呈负相关（r1＝－0．444，r2＝－0．535，P＜0．05）。结论高同型半胱氨酸血症为脑梗死的独立危险因素，与FA和VitB12水平下降有关。
목적：탐토혈청동형반광안산（Hcy）、협산（FA）급유생소B12（VitB12）수평여뇌경사적관계。방법채용순배매법화화학발광면역법분별검측60례뇌경사환자혈청 Hcy、FA급VitB12수평，병여동기40례건강체검자진행비교。결과뇌경사조혈청Hcy수평（23．16±8．17μmol／L）명현고우대조조（8．09±2．45μmol／L ，P＜0．01），혈청FA수평（6．12±2．19 ng／mL）화VitB12수평（323．92±133．79μmol／L）명현저우대조조（10．57±5．70 ng／mL ，530．85±168．56μmol／L ，P＜0．01）。뇌경사조혈청Hcy수평여FA급VitB12수평균정부상관（r1＝－0．444，r2＝－0．535，P＜0．05）。결론고동형반광안산혈증위뇌경사적독립위험인소，여FA화VitB12수평하강유관。
Objective To investigate the correlation between the serum levels of homocysteine (Hcy) ,folate acid (FA) and vita‐min B12 (VitB12 ) with cerebral infarction .Methods The enzymatic cycling method and chemiluminescence immunoassay were used to detect the serum Hcy ,FA and Vit B12 levels in 60 patients with cerebral infarction ,and then the detection results were compared the results of 40 people undergoing physical examination in the same period .Results The serum Hcy level in the cerebral infarction group was (23 .16 ± 8 .17)μmol/L ,which was significantly higher than (8 .09 ± 2 .45)μmol/L in the control group(P<0 .01) ,and the serum FA and Vit B12 levels in the cerebral infarction group were (6 .12 ± 2 .19) ng/mL and (323 .92 ± 133 .79)μmol/L ,which were in the control group lower than (10 .57 ± 5 .70) ng/mL and (530 .85 ± 168 .56)μmol/L in the control group (P<0 .01) .The serum Hcy level in the cerebral infarction group showed the negative correlation with FA and VitB 12 levels ( r1 = - 0 .444 , r2 = -0 .535 ,P<0 .05) .Conclusion High hyperhomocysteinemia is an independent risk factor of cerebral infarction and is related to the decrease of FA and VitB12 .