CAJ | 학술논문

目的：分析标本中铜绿假单胞菌（PAE）的临床分布和耐药情况，为临床医师用药提供指导。方法采用VITEC‐2 Compact全自动细菌鉴定及药敏分析系统，数据处理应用WHONET5．6软件，回顾性分析本院近4年间送检标本中PAE的检出情况、标本来源和耐药情况。结果 PAE的检出以下呼吸道标本为主，占送检标本的85％左右；对氨曲南、阿米卡星、环丙沙星、美洛培南和哌拉西林／他唑巴坦、哌拉西林、庆大霉素、头孢吡肟、头孢他啶、妥布霉素、亚胺培南、左氧氟沙星的耐药率呈逐年下降趋势，2013年除氨曲南耐药率为28．2％，其余抗菌药物均在10％左右。结论 PA E感染以呼吸道为主，及时合理监测其耐药性，为临床用药提供依据。
목적：분석표본중동록가단포균（PAE）적림상분포화내약정황，위림상의사용약제공지도。방법채용VITEC‐2 Compact전자동세균감정급약민분석계통，수거처리응용WHONET5．6연건，회고성분석본원근4년간송검표본중PAE적검출정황、표본래원화내약정황。결과 PAE적검출이하호흡도표본위주，점송검표본적85％좌우；대안곡남、아미잡성、배병사성、미락배남화고랍서림／타서파탄、고랍서림、경대매소、두포필우、두포타정、타포매소、아알배남、좌양불사성적내약솔정축년하강추세，2013년제안곡남내약솔위28．2％，기여항균약물균재10％좌우。결론 PA E감염이호흡도위주，급시합리감측기내약성，위림상용약제공의거。
Objective To analyze the clinical distribution and drug resistance of Pseudomonas aeruginosa (PAE) isolated from the samples to provide the guidance for the clinician′s medication .Methods The VITEC‐2 Compact system automatic bacterial i‐dentification and drug susceptibility analyzer was adopted to identify the isolated bacteria and conduct the drug sensitivity test ,the data were processed by the WHONET 5 .6 software .The PAE detection situation from the submitted specimens ,source and drug resistance were performed the retrospective analysis .Results The detected PAE strains were mainly isolated from the lower respir‐atory tract specimens ,accounting for 85 % of the submitted specimens ;the resistance rate to aztreonam ,amikacin ,ciprofloxacin , meropenem ,piperacillin/tazobactam ,piperacillin ,gentamicin ,cefepime ,ceftazidime ,tobramycin ,imipenem and levofloxacin showed the declining trend year by year .Except the resistant rate of aztreonam was 28 .2% in 2013 ,which of other antibiotics were at about 10% .Conclusion PAE infection is mainly in the respiratory tract ,its rug resistances should be timely and reasonably monitored to provide the basis for clinical medication .