CAJ | 학술논문

目的：探讨兰州地区乙型肝炎病毒（HBV）感染者血清中前S1抗原（Pre‐S1Ag）与 HBV DNA、HBV‐M 及肝功能之间的相关性。方法对905例 HBV 感染者（HBV 感染组）及100例健康体检者（健康对照组）进行 Pre‐S1Ag、HBV‐M、HBV DNA和肝功能检测。结果905例标本中，Pre‐S1Ag和HBV DNA阳性率分别为68．51％（620／905）和67．96％（615／905），差异均无统计学意义（χ2＝30．064，P＞0．05）；570例 HBeAg阳性组中，HBV Pre‐S1阳性率为85．08％（485／570），显著高于 HBeAg阴性组的 Pre‐SAg1阳性率40．30％（135／335），差异有统计学意义（χ2＝108．881，P＜0．01）。Pre‐S1 Ag阳性组与阴性组ALT、AST异常率分别为53．22％、25．96％和51．29％、32．98％，差异有统计学意义（χ2ALT ＝53．148，P＜ 0．001，χ2AST ＝66．635，P＜0．001）。结论 Pre‐S1Ag是乙肝病毒感染与复制的可靠指标，与HBV‐DNA阳性相关度高，是对 HBeAg的重要补充和加强，可为指导临床治疗提供更及时可靠的实验依据。
목적：탐토란주지구을형간염병독（HBV）감염자혈청중전S1항원（Pre‐S1Ag）여 HBV DNA、HBV‐M 급간공능지간적상관성。방법대905례 HBV 감염자（HBV 감염조）급100례건강체검자（건강대조조）진행 Pre‐S1Ag、HBV‐M、HBV DNA화간공능검측。결과905례표본중，Pre‐S1Ag화HBV DNA양성솔분별위68．51％（620／905）화67．96％（615／905），차이균무통계학의의（χ2＝30．064，P＞0．05）；570례 HBeAg양성조중，HBV Pre‐S1양성솔위85．08％（485／570），현저고우 HBeAg음성조적 Pre‐SAg1양성솔40．30％（135／335），차이유통계학의의（χ2＝108．881，P＜0．01）。Pre‐S1 Ag양성조여음성조ALT、AST이상솔분별위53．22％、25．96％화51．29％、32．98％，차이유통계학의의（χ2ALT ＝53．148，P＜ 0．001，χ2AST ＝66．635，P＜0．001）。결론 Pre‐S1Ag시을간병독감염여복제적가고지표，여HBV‐DNA양성상관도고，시대 HBeAg적중요보충화가강，가위지도림상치료제공경급시가고적실험의거。
Objective To investigate the correlations on hepatitis B virus (HBV) preS1‐antigen (pre‐S1Ag) with HBV‐DNA , HBV markers(HBV M) and liver function in the patients with hepatitis B .Methods The markers ,preS1‐Ag ,HBV‐DNA and liver function were determined by CLIA and PCR in 905 patients with hepatitis B (HBV infection group ) and 100 healthy persons (healthy control group) .Results Among 905 samples ,the positive rates of preS1‐Ag and HBV DNA were 68 .51% (620/905) and 67 .96% (615/905) ,there was no statistically significant difference between them (χ2 =30 .064 ,P>0 .05);the positive rates of pre‐S1Ag in 570 patients with HBeAg positive were 85 .08% (485/570) ,which was significantly higher than 40 .30% (135/335) in 335 patients with HBeAg negative ,the difference was statistically significant (χ2 =108 .881 ,P<0 .01) .The abnormal rates of ALT and AST in the Pre‐S1 Ag positive and negative groups were 53 .22% ,25 .96% and 51 .29% ,32 .98% ,respectively ,the differences be‐tween them were statistically significant (χ2ALT =53 .148 ,P<0 .001 ,χ2AST =66 .635 ,P<0 .001) .Conclusion Pre‐S1Ag is a reliable index of the HBV infection and duplication and is highly correlated with HBV‐DNA positive ,which is important supplement and strengthening and can provide more timely and reliable experiment basis for guiding the clinical treatment .