CAJ | 학술논문

目的：调查本院2012年10月至2013年9月患病儿童送检标本中分离出铜绿假单胞菌的感染状况以及亚胺培南耐药株的药敏分析。掌握广州地区儿童感染铜绿假单胞菌对抗菌药物的耐药状况及耐亚胺培南菌株的发生情况。方法分析2012年10月至2013年9月儿童送检感染标本的铜绿假单胞菌检出情况，采用法国生物梅里埃公司的VIT EK 2 Compact分析仪进行细菌鉴定，检测对亚胺培南耐药铜绿假单胞菌对11种抗菌药物的最低抑菌浓度（M IC ）。结果从36600例标本中共检出161株铜绿假单胞菌，其中耐亚胺培南铜绿假单胞菌24株占14．9％；阳性菌株主要来源于痰标本，高达50．3％，分离最高的是IC U和N IC U ，分别占27．4％和21．8％。耐亚胺培南铜绿假单胞菌对头孢曲松、头孢哌酮、头孢他啶、头孢哌酮／舒巴坦、氨曲南的耐药率比较高，分别是91．7％、29．0％、29．0％、29．0％和25．0％。结论耐亚胺培南的铜绿假单胞菌在本地区儿童中检出率较高，常对其他抗菌药物多重耐药，应引起高度重视，合理使用抗菌药物。
목적：조사본원2012년10월지2013년9월환병인동송검표본중분리출동록가단포균적감염상황이급아알배남내약주적약민분석。장악엄주지구인동감염동록가단포균대항균약물적내약상황급내아알배남균주적발생정황。방법분석2012년10월지2013년9월인동송검감염표본적동록가단포균검출정황，채용법국생물매리애공사적VIT EK 2 Compact분석의진행세균감정，검측대아알배남내약동록가단포균대11충항균약물적최저억균농도（M IC ）。결과종36600례표본중공검출161주동록가단포균，기중내아알배남동록가단포균24주점14．9％；양성균주주요래원우담표본，고체50．3％，분리최고적시IC U화N IC U ，분별점27．4％화21．8％。내아알배남동록가단포균대두포곡송、두포고동、두포타정、두포고동／서파탄、안곡남적내약솔비교고，분별시91．7％、29．0％、29．0％、29．0％화25．0％。결론내아알배남적동록가단포균재본지구인동중검출솔교고，상대기타항균약물다중내약，응인기고도중시，합리사용항균약물。
Objective To investigate the infection status and drug resistance of imipenem‐resistant Pseudomonas aeruginosa (PAE) isolated from the submitted specimens from children patients in our hospital between October 2012 to September 2013 for mastering the antimicrobial resistance status of Pseudomonas aeruginosa infection among children in Guangzhou and the occurrence situation of imipenem resistant strains .Methods The detection situation of Pseudomonas aeruginosa from infected children during this period was analyzed and the VITEK 2 Compact analyzer produced by the France bioMerieux company was used to identify the bacteria .The minimal inhibitory concentration(MIC) of imipenem resistant Pseudomonas aeruginosa to 11 kinds of antibiotics was detected .Results 161 strains of Pseudomonas aeruginosa were detected from 36 600 specimens ,including 24 strains(14 .9% ) of imipenem resistant Pseudomonas aeruginosa ,the positive strains were mainly originated from phlegmy (50 .3% ) ,the isolation was highest in ICU (27 .4% ) and NICU(21 .8% ) .The drug resistance rate of imipenem‐resistant P .aeruginosa was higher to ceftriax‐one sodium(91 .7% ) ,cefoperazone(29 .0% ) ,ceftazidime(29 .0% ) ,cefoperazone /shubatan(29 .0% ) and aztreonam (25 .0% ) .Con‐clusion Imipenem‐resistant Pseudomonas aeruginosa has the higher detection rate among children in this area and usually has re‐sistance to multiple antibiotics ,which should be paid more attention to and antibiotics should be rationally used .