CAJ | 학술논문

目的：探讨粒系集落刺激因子（G‐CSF）动员健康供者外周血造血干细胞效果的影响因素。方法对24例健康供者皮下注射G‐CSF动员造血干细胞，检测外周血 T 淋巴细胞亚群和血常规数据。结果经 G‐CSF刺激后，外周血CD3＋（％）、CD3＋CD4＋（％）、白细胞计数、血小板均明显升高（P＜0．05）；而动员第4天、第5天、第6天骨有核细胞密度、CD34＋细胞百分比无明显差别。经相关性分析，性别、年龄、体质量与CD34＋细胞百分比呈负相关（ P＜0．05），白细胞计数呈正相关（ P＜0．01）。结论在一定范围内男性供者优于女性供者，年龄越小，体质量越轻，白细胞计数越高，经G‐CSF动员的外周血造血干细胞CD34＋细胞百分比越高。
목적：탐토립계집락자격인자（G‐CSF）동원건강공자외주혈조혈간세포효과적영향인소。방법대24례건강공자피하주사G‐CSF동원조혈간세포，검측외주혈 T 림파세포아군화혈상규수거。결과경 G‐CSF자격후，외주혈CD3＋（％）、CD3＋CD4＋（％）、백세포계수、혈소판균명현승고（P＜0．05）；이동원제4천、제5천、제6천골유핵세포밀도、CD34＋세포백분비무명현차별。경상관성분석，성별、년령、체질량여CD34＋세포백분비정부상관（ P＜0．05），백세포계수정정상관（ P＜0．01）。결론재일정범위내남성공자우우녀성공자，년령월소，체질량월경，백세포계수월고，경G‐CSF동원적외주혈조혈간세포CD34＋세포백분비월고。
Objective To investigate the influence factors of peripheral blood hematopoietic stem cell of healthy donor by granu‐locyte colony‐stimulating‐factors(G‐CSF) mobilization .Methods G‐CSF was subcutaneously injected in 24 cases of healthy donor for mobilizing hematopoietic stem cells .The T lymphocyte subgroup and blood routine data were detected .Results After G‐CSF stimulation ,peripheral blood CD3+ (% ) ,CD3+CD4+ (% ) ,white blood cell (WBC) count and platelet were significantly increased (P<0 .05) .And nucleated cells density of bone ,percentage of CD34+ cells on mobilized 4 ,5 ,6 d had no obvious difference .The correlation analysis showed that gender ,age and weight were negatively correlated with CD 34+cells percentage (P<0 .05) and pos‐itively correlated with WBC count (P<0 .01) .Conclusion Male donor is superior to female donor within a certain range ,the smal‐ler age ,the lighter weight ,the higher WBC count ,the higher the percentage of CD34+ cells in peripheral blood hematopoietic stem cells after G‐CSF mobilization .