CAJ | 학술논문

目的：研究无偿献血者丙氨酸氨基转移酶（ALT）不合格与乙型肝炎表面抗原（HBsAg）、丙型肝炎抗体（抗‐HCV）检测的相关性，并探讨降低血液报废率的措施。方法对2009年1月1日至2013年12月31日深圳市血液中心330633例无偿献血者血液标本进行ALT、HBsAg、抗‐HCV检测并进行丙氨酸氨基转移酶与病毒性肝炎相关性分析。结果检测的330633例标本中ALT检测阳性的标本932例，占献血总人次的0．282％；病毒性肝炎阳性标本2965例，占献血总人次的0．897％，两者差异具有统计学意义（P＜0．05）。ALT不合格，但病毒性肝炎阴性标本915例，占ALT不合格人数的98．176％；由ALT检测所造成的血液报废率为0．277％（915／330633）。结论ALT不合格率与病毒性肝炎检出率存在统计学差异，进行ALT检测的预期病毒性肝炎的符合率较低，许多假阳性导致了正常血液的报废。因此，ALT检测作为病毒性肝炎的辅助检查指标是否继续沿用仍有待商榷。
목적：연구무상헌혈자병안산안기전이매（ALT）불합격여을형간염표면항원（HBsAg）、병형간염항체（항‐HCV）검측적상관성，병탐토강저혈액보폐솔적조시。방법대2009년1월1일지2013년12월31일심수시혈액중심330633례무상헌혈자혈액표본진행ALT、HBsAg、항‐HCV검측병진행병안산안기전이매여병독성간염상관성분석。결과검측적330633례표본중ALT검측양성적표본932례，점헌혈총인차적0．282％；병독성간염양성표본2965례，점헌혈총인차적0．897％，량자차이구유통계학의의（P＜0．05）。ALT불합격，단병독성간염음성표본915례，점ALT불합격인수적98．176％；유ALT검측소조성적혈액보폐솔위0．277％（915／330633）。결론ALT불합격솔여병독성간염검출솔존재통계학차이，진행ALT검측적예기병독성간염적부합솔교저，허다가양성도치료정상혈액적보폐。인차，ALT검측작위병독성간염적보조검사지표시부계속연용잉유대상각。
Objective To study the correlation between alanie aminotransferase(ALT) unqualified samples and hepatitis B sur‐face antigen(HBsAg) and hepatitis C virus antibody (anti‐HCV) detection and to investigate an effective measure for reducing the discard rate of donated blood .Methods 330 633 blood samples donated by volunteers in Shenzhen Municipal Blood Center from January 1 ,2009 to December 31 ,2013 were performed the ALT ,HBsAg and anti‐HCV detection .Then the correlation between the detection results of ALT and viral hepatitis .Results Among 33 0633 donated blood samples ,there were 932 cases (0 .282% ) of ALT positive and 2 965 cases (0 .897% ) of viral hepatitis positive ,the differences were statistically significant (P<0 .05) .915 cases were unqualified in ALT ,but negative in viral hepatitis ,which accounting for 98 .176% of all ALT unqualified samples ;the blood discard rate generated by ALT disqualification was 0 .277% (915/330633) .Conclusion Our study indicates that the statistical difference exists in the ALT unqualified rate and the viral hepatitis detection rate ,conducting the ALT detection has the lower coin‐cidence rate for expected viral hepatic ,many false positive lead to the discard of normal blood .Therefore ,whether to continue using the ALT detection as the auxillary detection indicator is still being negotiated .