CAJ | 학술논문

目的：探究外周血人软骨糖蛋白‐39在原发性干燥综合征患者中的检测价值。方法选取2011年7月至2014年7月本院收治的首次诊断为原发性干燥征的患者50例，为原发性干燥综合征组，另外选取同期来本院体检健康志愿者50例，作为健康对照组；抽取静脉血，测量并对比患者和志愿者红细胞沉降率（ESR）、C‐反应蛋白（CPR）和人软骨糖蛋白‐39水平等，并检查对比口唇腺体淋巴细胞病灶数和唾液流率等。结果原发性干燥综合征组患者外周血人软骨糖蛋白‐39明显高于健康对照组志愿者（ t＝25．207，P＜0．001）。原发性干燥综合征患者外周血人软骨糖蛋白‐39水平与口唇腺体淋巴细胞病灶数（ r＝ 0．46，P＝0．001）、ESR（r＝0．48，P＝0．001）、CRP（r＝0．70，P＜0．001）、RF（r＝0．41，P＝0．004）、IgG（r＝0．50，P＜0．001）成正相关，与唾液流率（ r＝－0．42，P＝0．003）成负相关。有并发症的原发性干燥综合征患者外周血人软骨糖蛋白‐39水平（252．4±23．5）μg／L明显高于无并发症患者（174．6±21．7）μg／L ，差异有统计学意义（t＝11．678，P＜0．001）。结论人软骨糖蛋白‐39可作为判断原发性干燥综合征疾病活动度的指标，其水平明显升高还可提示患者可能发生并发症，为较客观、全面地反映pSS病情的指标，可广泛应用于临床。
목적：탐구외주혈인연골당단백‐39재원발성간조종합정환자중적검측개치。방법선취2011년7월지2014년7월본원수치적수차진단위원발성간조정적환자50례，위원발성간조종합정조，령외선취동기래본원체검건강지원자50례，작위건강대조조；추취정맥혈，측량병대비환자화지원자홍세포침강솔（ESR）、C‐반응단백（CPR）화인연골당단백‐39수평등，병검사대비구진선체림파세포병조수화타액류솔등。결과원발성간조종합정조환자외주혈인연골당단백‐39명현고우건강대조조지원자（ t＝25．207，P＜0．001）。원발성간조종합정환자외주혈인연골당단백‐39수평여구진선체림파세포병조수（ r＝ 0．46，P＝0．001）、ESR（r＝0．48，P＝0．001）、CRP（r＝0．70，P＜0．001）、RF（r＝0．41，P＝0．004）、IgG（r＝0．50，P＜0．001）성정상관，여타액류솔（ r＝－0．42，P＝0．003）성부상관。유병발증적원발성간조종합정환자외주혈인연골당단백‐39수평（252．4±23．5）μg／L명현고우무병발증환자（174．6±21．7）μg／L ，차이유통계학의의（t＝11．678，P＜0．001）。결론인연골당단백‐39가작위판단원발성간조종합정질병활동도적지표，기수평명현승고환가제시환자가능발생병발증，위교객관、전면지반영pSS병정적지표，가엄범응용우림상。
Objective To explore the detection value of peripheral blood human cartilage glycoprotein‐39 in the patients with pri‐mary Sjogren′s syndrome(pSS) .Methods 50 patients with newly diagnosed pSS in our hospital from July 2011 to July 2014 were selected as the pSS group and contemporaneous 50 individuals undergoing physical examination were selected as the normal control group .Venous blood was sampled in all subjects and the erythrocyte sedimentation rate (ESR) ,C‐reactive protein (CRP) ,human cartilage glycoprotein‐39 levels were measured and compared .The lesion number of oral gland lymphocytes and saliva flow rate were checked and compared .Results The pSS group had significantly higher peripheral blood human cartilage glycoprotein‐39 than the normal control group (t=25 .207 ,P<0 .001) .The peripheral blood human cartilage glycoprotein‐39 level in the patients with pSS was positively correlated with the lesion number of oral gland lymphocytes (r=0 .46 ,P=0 .001) ,ESR(r=0 .48 ,P=0 .001) , CRP(r=0 .70 ,P<0 .001) ,RF(r=0 .41 ,P=0 .004) and IgG (r=0 .50 ,P<0 .001) ,and negatively correlated with the saliva flow rate (r= -0 .42 ,P=0 .003) .The eripheral blood human cartilage glycoprotein‐39 level in the patients with pSS and complications was (252 .4 ± 23 .5)μg/L ,which was significantly higher than (174 .6 ± 21 .7) μg/L in the patients without complications (t=11 .678 ,P<0 .001) .Conclusion Human cartilage glycoprotein‐39 can serve as the disease activity index of pSS and its significant increase can prompt that the patient may have complications .Human cartilage glycoprotein‐39 is also an index reflecting the disease condition of pSS objectively and comprehensively and can be widely used in clinic .