国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2015年
7期
952-953
,共2页
亮氨酸氨基肽酶%甲状腺功能亢进%甲状腺激素
亮氨痠氨基肽酶%甲狀腺功能亢進%甲狀腺激素
량안산안기태매%갑상선공능항진%갑상선격소
leucine aminopeptidase%hyperthyroidism%thyroid hormone
目的：检测甲状腺功能亢进患者血清亮氨酸氨基肽酶（leucine aminopeptidase ，LAP）指标，探讨LAP在甲状腺功能异常患者中的变化及其临床意义。方法选取117例甲状腺功能亢进（简称甲亢）患者作为试验组，109例健康者作为对照组。对比分析不同组间各项实验室指标的差异，并进行LAP和FT3、FT4、TSH的相关性分析。将117例甲亢患者分为肝损害组52例，肝未损害组65例，并进行LAP测定。结果甲亢整体组、甲亢肝损害组、甲亢肝未损害组LAP和FT3、FT4、TSH与正常对照组对比均有统计学差异（P＜0．01），血清LAP与FT3、FT4成正相关，与TSH成负相关；甲亢肝损害组LAP和FT3、FT4、TSH与甲亢肝未损伤组对比无统计学差异（P＞0．05）。结论血清LAP含量与甲状腺激素关系密切，对甲状腺功能亢进患者诊断、病情评估、以及治疗用药有一定的临床参考价值。LAP可以作为甲亢的一个独立诊断指标。
目的：檢測甲狀腺功能亢進患者血清亮氨痠氨基肽酶（leucine aminopeptidase ，LAP）指標，探討LAP在甲狀腺功能異常患者中的變化及其臨床意義。方法選取117例甲狀腺功能亢進（簡稱甲亢）患者作為試驗組，109例健康者作為對照組。對比分析不同組間各項實驗室指標的差異，併進行LAP和FT3、FT4、TSH的相關性分析。將117例甲亢患者分為肝損害組52例，肝未損害組65例，併進行LAP測定。結果甲亢整體組、甲亢肝損害組、甲亢肝未損害組LAP和FT3、FT4、TSH與正常對照組對比均有統計學差異（P＜0．01），血清LAP與FT3、FT4成正相關，與TSH成負相關；甲亢肝損害組LAP和FT3、FT4、TSH與甲亢肝未損傷組對比無統計學差異（P＞0．05）。結論血清LAP含量與甲狀腺激素關繫密切，對甲狀腺功能亢進患者診斷、病情評估、以及治療用藥有一定的臨床參攷價值。LAP可以作為甲亢的一箇獨立診斷指標。
목적：검측갑상선공능항진환자혈청량안산안기태매（leucine aminopeptidase ，LAP）지표，탐토LAP재갑상선공능이상환자중적변화급기림상의의。방법선취117례갑상선공능항진（간칭갑항）환자작위시험조，109례건강자작위대조조。대비분석불동조간각항실험실지표적차이，병진행LAP화FT3、FT4、TSH적상관성분석。장117례갑항환자분위간손해조52례，간미손해조65례，병진행LAP측정。결과갑항정체조、갑항간손해조、갑항간미손해조LAP화FT3、FT4、TSH여정상대조조대비균유통계학차이（P＜0．01），혈청LAP여FT3、FT4성정상관，여TSH성부상관；갑항간손해조LAP화FT3、FT4、TSH여갑항간미손상조대비무통계학차이（P＞0．05）。결론혈청LAP함량여갑상선격소관계밀절，대갑상선공능항진환자진단、병정평고、이급치료용약유일정적림상삼고개치。LAP가이작위갑항적일개독립진단지표。
Objective To detect serum leucine aminopeptidase (LAP) level in the patients with hyperthyroidism for investiga‐ting the changes of LAP in the patients with thyroid dysfunction and its clinical significance .Methods 117 patients with hyperthy‐roidism were taken as the test group and 109 healthy people as the control group .The differences of various laboratory indexes were comparatively analyzed and the correlation between LAP with FT 3 ,FT4 and TSH was analyzed .117 patients with hyperthyroidism were divided into the liver damage group(52 cases) and non‐liver damage group(65 cases) and performed the LAP determination . Results The serum LAP ,FT3 ,FT4 and TSH levels in the hyperthyroidism whole group ,hyperthyroidism liver damage group and hyperthyroidism non‐liver damage group had statistically significant differences compared with those in the control group (P<0 .01) ,serum LAP was positively correlated with FT 3 and FT4 ,and negatively correlated with TSH ;LAP ,FT3 ,FT4 and TSH had no statistical differences between the hyperthyroidism live damage group and the hyperthyroidism non‐liver damage group (P>0 .05) .Conclusion The serum LAP content is closely related with the thyroid hormones and has certain clinical reference value for the diagnosis ,disease condition evaluation and medication .Lap can serve as an independent diagnostic indicator .
