临床肝胆病杂志
臨床肝膽病雜誌
림상간담병잡지
CHINESE JOURNAL OF CLINICAL HEPATOLOGY
2015年
4期
630-634
,共5页
沈敏(综述)%范怀艳%韦嘉(审校)
瀋敏(綜述)%範懷豔%韋嘉(審校)
침민(종술)%범부염%위가(심교)
脂肪肝%Toll样受体4%综述
脂肪肝%Toll樣受體4%綜述
지방간%Toll양수체4%종술
fatty liver%Toll-like receptor 4%review
非酒精性脂肪性肝病（NAFLD）常发生于具有代谢综合征特点的患者，主要临床病理表现为肝实质细胞脂肪变性和脂肪贮积，可进展为肝硬化，最终发生肝衰竭。Toll样受体（TLR）4信号途径参与NAFLD的发生发展。目前，TLR4在NAFLD发病中所起到的作用引起临床医师高度重视。简述了TLR4的结构、TLR4信号途径的构成、表达调节方式、功能及其与NAFLD的关系，认为未来TLR4信号途径必然成为治疗NAFLD的重要研究领域。
非酒精性脂肪性肝病（NAFLD）常髮生于具有代謝綜閤徵特點的患者，主要臨床病理錶現為肝實質細胞脂肪變性和脂肪貯積，可進展為肝硬化，最終髮生肝衰竭。Toll樣受體（TLR）4信號途徑參與NAFLD的髮生髮展。目前，TLR4在NAFLD髮病中所起到的作用引起臨床醫師高度重視。簡述瞭TLR4的結構、TLR4信號途徑的構成、錶達調節方式、功能及其與NAFLD的關繫，認為未來TLR4信號途徑必然成為治療NAFLD的重要研究領域。
비주정성지방성간병（NAFLD）상발생우구유대사종합정특점적환자，주요림상병리표현위간실질세포지방변성화지방저적，가진전위간경화，최종발생간쇠갈。Toll양수체（TLR）4신호도경삼여NAFLD적발생발전。목전，TLR4재NAFLD발병중소기도적작용인기림상의사고도중시。간술료TLR4적결구、TLR4신호도경적구성、표체조절방식、공능급기여NAFLD적관계，인위미래TLR4신호도경필연성위치료NAFLD적중요연구영역。
Nonalcoholic fatty liver disease (NAFLD)is prevalent in patients with characteristics of metabolic syndrome.The main clinico-pathological manifestations of NAFLD are fatty degeneration of liver parenchyma cells and fat storage,which can progress to liver cirrhosis and eventually lead to liver failure.Toll -like receptor 4 (TLR4)signaling pathway is involved in the development and progression of NAFLD.At present,the role of TLR4 in the onset of NAFLD is highly valued by clinical doctors.This paper reviews the structure of TLR4, the composition of TLR4 signaling pathway,the regulation of TLR4 expression,the function of TLR4,and the relationship between TLR4 and NAFLD,suggesting that TLR4 signaling pathway is going to be an important research field in the treatment of NAFLD in the future.
