CAJ | 학술논문

目的：评估基础胰岛素联合口服降糖药（OADs）用于治疗以预混胰岛素联合或不联合OADs为降糖方案的血糖控制欠佳的2型糖尿病（T2DM ）患者的有效性及安全性。方法32例预混胰岛素联合或不联合OADs治疗血糖控制欠佳的T2DM患者，停止正在使用的预混胰岛素，改用甘精胰岛素联合OADs治疗16周，比较受试者治疗前后糖化血红蛋白（HbA1c）、空腹血糖（FBG）、餐后血糖（PBG）、体质量指数（BMI）和胰岛素剂量，并记录低血糖事件发生情况。结果32例患者均完成研究，经甘精胰岛素治疗16周后，受试者HbA1c、FBG、BMI均较治疗前明显下降（P＜0．01）。甘精胰岛素使用剂量较入组时预混胰岛素剂量显著减少（P＜0．01）。治疗期间有2例（6．2％）受试者发生低血糖事件2次，均为一般性低血糖。结论每日1次基础胰岛素能有效改善预混胰岛素加或不加OADs治疗失败的T2DM 患者的糖代谢，并且不增加体质量。
목적：평고기출이도소연합구복강당약（OADs）용우치료이예혼이도소연합혹불연합OADs위강당방안적혈당공제흠가적2형당뇨병（T2DM ）환자적유효성급안전성。방법32례예혼이도소연합혹불연합OADs치료혈당공제흠가적T2DM환자，정지정재사용적예혼이도소，개용감정이도소연합OADs치료16주，비교수시자치료전후당화혈홍단백（HbA1c）、공복혈당（FBG）、찬후혈당（PBG）、체질량지수（BMI）화이도소제량，병기록저혈당사건발생정황。결과32례환자균완성연구，경감정이도소치료16주후，수시자HbA1c、FBG、BMI균교치료전명현하강（P＜0．01）。감정이도소사용제량교입조시예혼이도소제량현저감소（P＜0．01）。치료기간유2례（6．2％）수시자발생저혈당사건2차，균위일반성저혈당。결론매일1차기출이도소능유효개선예혼이도소가혹불가OADs치료실패적T2DM 환자적당대사，병차불증가체질량。
Objective To observe the effectiveness and safety of basal insulin plus oral antidiabetic drugs (OADs) in treating the patients with type 2 diabetic mellitus (T2DM ) ,who were poor blood sugar control by premixed insulin with or without OADs . Methods 32 cases of T2DM and poor blood sugar control by premixed insulin combinated with or without OADs stopped the premixed insulin therapy and changed to insulin glargine plus OADs for 16 weeks .Glycosylated haemoglobin (HbA1c) ,fasting blood glucose(FBG) ,postprandial blood glucose(PBG) ,body mass index (BMI) and mean daily insulin dose were compared among patients .And the episodes of hypoglycemia events were recorded .Results After 16‐week treatment ,HbA1c ,FBG ,PBG and BMI were all significantly decreased comapared with before treatment (P<0 .01) .The mean insulin glargine daily dose was significantly decreased compared with the premixed insulin dose at admission .2 cases (6% )appeared twice hypoglycemia episodes during the treatment period ,all were general hypoglycemia .Conclusion Basal insulin once daily can effectively improve the sugar metabolism in T2DM patients failed by premixed insulin with or without OADs ,moreover the body mass is not increased .