CAJ | 학술논문

微 RNA（miRNA）是一组高度保守的长度约22个核苷酸的非编码 RNA，通过靶定相应的互补序列导致 mRNA 的沉默或者抑制翻译以调节基因和蛋白的表达。急性肺损伤／急性呼吸窘迫综合征（ALI ／ARDS）的发病机制错综复杂，涉及失控性炎症反应、细胞凋亡及肺泡液体清除异常等多个层面，而且各个层面相互影响形成复杂的细胞网络和细胞因子网络，其通过不同的信号转导通路调控机体炎症反应。ALI 发病过程中 miRNA 表达异常，miRNA 可通过与靶 mRNA 部分结合在转录和转录后水平调节靶基因表达，参与 ALI 的整个发病过程。本文总结了国内外 ALI 发病过程中相关miRNA 的研究进展，旨在寻找和验证 miRNA 在 ALI 炎症激活和信号转导途径中的作用，为 ALI 的诊疗提供新靶点。
미 RNA（miRNA）시일조고도보수적장도약22개핵감산적비편마 RNA，통과파정상응적호보서렬도치 mRNA 적침묵혹자억제번역이조절기인화단백적표체。급성폐손상／급성호흡군박종합정（ALI ／ARDS）적발병궤제착종복잡，섭급실공성염증반응、세포조망급폐포액체청제이상등다개층면，이차각개층면상호영향형성복잡적세포망락화세포인자망락，기통과불동적신호전도통로조공궤체염증반응。ALI 발병과정중 miRNA 표체이상，miRNA 가통과여파 mRNA 부분결합재전록화전록후수평조절파기인표체，삼여 ALI 적정개발병과정。본문총결료국내외 ALI 발병과정중상관miRNA 적연구진전，지재심조화험증 miRNA 재 ALI 염증격활화신호전도도경중적작용，위 ALI 적진료제공신파점。
miRNA are a group of highly conserved small non-coding RNAs,22 nucleotides in length,that regulate gene and protein expression by binding the appropriate complementary sequences caused silence of mRNA or inhibiting translation.The pathogenesis of ALI /ARDS is so complicated that involves uncontrolled inflammatory response,apoptosis and alveolar fluid clearance and other levers.But all levels influence each other to form a complicated cells and inflammatory factors network which regulate the body′s inflammatory response through different signal transmission pathway.In the course of ALI,abnormal expression of miRNA which regulate target gene expression on transcription or post-transcription by partially combining target mRNA and articipate in the whole process of ALI.This article summarizes the research progresses of miRNA with ALI at home and abroad which aims to find and verify the roles of miRNA in the activation of the inflammatory response and signal transduction pathway,offering new targets for diagnosis and treatment of ALI.